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一例罕见的由……引起的小脑脓肿病例。 (原文此处“caused by”后缺少具体病因内容)

A rare case of cerebellar abscess caused by .

作者信息

Koruga Nenad, Reljac Gordan, Rončević Alen, Bogdan Maja, Sabadi Dario, Farčić Nikolina, Rotim Tatjana, Turk Tajana, Rončević Robert, Soldo Koruga Anamarija, Dmitrović Branko

机构信息

Department of Neurosurgery, University Hospital Center Osijek, Osijek, Croatia.

Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.

出版信息

Surg Neurol Int. 2024 Nov 15;15:413. doi: 10.25259/SNI_426_2024. eCollection 2024.

Abstract

BACKGROUND

Gram-positive opportunistic bacteria of the species are responsible for a large spectrum of infections, such as pneumonia, skin infections, and more widespread conditions, including brain abscesses.

CASE DESCRIPTION

A 67-year-old male patient suffered from headache, gait disorder, and vertigo for a week before admission to our department. An enhanced magnetic resonance imaging scan revealed a mediosagittal hyperintense infratentorial lesion with concomitant compression of the fourth ventricle. The patient underwent surgical treatment with general anesthesia. The frozen section did not reveal any tumoral tissue but rather a purulent content. He was comatose on the 1 postoperative day, and he underwent a follow-up computed tomography (CT) scan, which revealed triventricular hydrocephalus. The external ventricular drain was performed, and a follow-up CT scan revealed significant improvement of hydrocephalus. Matrix-Assisted Laser Desorption Ionization Time of Flight did not reveal any causative agent from the intraoperative content, but the 16s ribosomal DNA method confirmed . The patient was intravenously treated with ceftriaxone and trimethoprim/sulfamethoxazole and died on the 5 postoperative day.

CONCLUSION

Nocardiosis presents a rare Gram-positive bacterial infection that typically affects immunocompromised hosts. -caused brain abscesses present a significant challenge in its treatment for its atypical presentation and slow culture growth.

摘要

背景

该菌种的革兰氏阳性机会致病菌可引发多种感染,如肺炎、皮肤感染以及包括脑脓肿在内的更广泛病症。

病例描述

一名67岁男性患者在入院前一周出现头痛、步态障碍和眩晕症状。增强磁共振成像扫描显示幕下中矢状位高强度病变,同时伴有第四脑室受压。患者在全身麻醉下接受了手术治疗。冰冻切片未发现任何肿瘤组织,而是发现了脓性内容物。术后第1天患者昏迷,随后进行了计算机断层扫描(CT)随访,结果显示三脑室积水。进行了脑室引流,后续CT扫描显示脑积水有明显改善。基质辅助激光解吸电离飞行时间质谱分析未从术中内容物中发现任何致病因子,但16S核糖体DNA方法证实了[此处原文似乎不完整]。患者接受了头孢曲松和甲氧苄啶/磺胺甲恶唑静脉治疗,术后第5天死亡。

结论

诺卡菌病是一种罕见的革兰氏阳性细菌感染,通常影响免疫功能低下的宿主。由[此处原文似乎不完整]引起的脑脓肿因其非典型表现和培养生长缓慢,在治疗上具有重大挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9be2/11618760/676ce763d237/SNI-15-413-g001.jpg

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