Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, Ningbo 315201, P. R. China.
University of Chinese Academy of Sciences, No. 1 Yanqihu East Road, Huairou District, Beijing, 101408, China.
Nanoscale. 2023 Jun 30;15(25):10513-10528. doi: 10.1039/d3nr01373a.
Iron (Fe)-based nanoparticles (NPs) represented by FeO exhibit attractive properties, such as high saturation magnetization, low magneto-crystalline anisotropy, and good biocompatibility, and are useful as magnetic resonance imaging (MRI) contrast agents. However, the existence of artifacts makes the single magnetic resonance imaging mode lack accuracy in tumor diagnosis. To overcome this limitation, a strategy where rare-earth elements are combined with Fe-based NPs is applied. Rare earth is the general name of Sc, Y, and elements with unique 4f electronic configurations. Some rare-earth elements like Gd and Lu exhibit magnetic properties due to unpaired electrons, while some, like Er and Ho, fluoresce under excitation ascribed to the electron transition at intermediate energy levels. In this manuscript, attention is focused on multimodal nanomaterials composed of rare-earth elements and Fe-based NPs. We provide an overview of the synthetic routes and current biomedical application of the nanocomposites that show potential for precise diagnosis and efficient treatment of cancers.
以 FeO 为代表的铁基纳米粒子 (NPs) 表现出诱人的特性，如高饱和磁化强度、低磁晶各向异性和良好的生物相容性，可用作磁共振成像 (MRI) 造影剂。然而，伪影的存在使得单一磁共振成像模式在肿瘤诊断中的准确性不足。为了克服这一限制，采用了将稀土元素与铁基 NPs 结合的策略。稀土是 Sc、Y 和具有独特 4f 电子构型的元素的统称。一些稀土元素，如 Gd 和 Lu，由于不成对电子而表现出磁性，而一些元素，如 Er 和 Ho，在中间能级的电子跃迁激发下发光。在本文中，重点关注由稀土元素和铁基 NPs 组成的多模态纳米材料。我们提供了对纳米复合材料的合成途径和当前生物医学应用的概述，这些复合材料有望实现癌症的精确诊断和有效治疗。
