Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, China, 430070.
Department of Medical Ultrasound, China Resources and Wisco General Hospital, Wuhan University of Science and Technology, Wuhan, China, 430080.
ACS Sens. 2022 Oct 28;7(10):2857-2864. doi: 10.1021/acssensors.2c01468. Epub 2022 Oct 3.
Ultrasound imaging is regarded as a highly sensitive imaging modality used in routine clinical examinations. Over the last several decades, ultrasound contrast agents have been widely applied in ultrasound molecular cancer imaging to improve the detection, characterization, and quantification of tumors. To date, a few new potential preclinical and clinical applications regarding ultrasound molecular cancer imaging are being investigated. This review presents an overview of the various kinds of ultrasound contrast agents employed in ultrasound molecular imaging and advanced imaging techniques using these contrast agents. Additionally, we discuss the recent enormous development of ultrasound contrast agents in the relevant preclinical and clinical applications, highlight the recent challenges which need to be overcome to accelerate the clinical translation, and discuss the future perspective of ultrasound molecular cancer imaging using various contrast agents. As a highly promising and valuable tumor-specific imaging technique, it is believed that ultrasound molecular imaging will pave an accurate and efficient way for cancer diagnosis.
超声成像是一种高度敏感的成像方式，常用于常规临床检查。在过去的几十年中，超声造影剂已广泛应用于超声分子癌症成像中，以提高肿瘤的检测、特征描述和定量。迄今为止，一些新的潜在的超声分子癌症成像的临床前和临床应用正在被研究。本综述介绍了各种用于超声分子成像的超声造影剂，以及使用这些造影剂的高级成像技术。此外，我们还讨论了超声造影剂在相关临床前和临床应用中的最新巨大发展，强调了为加速临床转化需要克服的近期挑战，并探讨了使用各种造影剂的超声分子癌症成像的未来展望。作为一种极具前景和有价值的肿瘤特异性成像技术，超声分子成像有望为癌症诊断提供一种准确而高效的方法。
