Tao Xianyao, Pan Xiaoyun, Zhao Gang, Rui Yongjun
Wuxi Ninth People' s Hospital Affiliated to Soochow University, Department of Hand Surgery, Wuxi, Jiangsu, 214062, China.
Heliyon. 2024 Sep 11;10(20):e37846. doi: 10.1016/j.heliyon.2024.e37846. eCollection 2024 Oct 30.
The beneficial effect of myokine irisin on ischemia-reperfusion of skin flaps has been rarely reported in clinical studies. This study was designed to determine whether irisin plays a protective role in flap transplantation and identify the factors affecting serum irisin levels.
We analyzed the changes in serum irisin levels and flap blood flow before and after surgery in 40 patients who underwent skin-flap transplantation. Factors affecting serum irisin levels were analyzed by metabolic parameter measurements.
Preoperative serum irisin levels were positively correlated with blood flow in the skin flap 7 days post-surgery. The increase in serum irisin levels in the first 3 days after surgery positively correlated with flap blood flow. A longer duration of high-intensity exercise, higher skeletal muscle content, lower body mass index, and waist-to-hip ratio were associated with higher irisin levels. Fasting blood glucose and glycosylated hemoglobin levels showed significant negative correlations with serum irisin levels. Several other indicators, including sex, were not associated with serum irisin levels.
Serum irisin levels benefit blood flow recovery during flap transplantation. Better outcomes may be achieved by adjusting the timing and intensity of the exercise and controlling the patient's body size.
在临床研究中，肌动蛋白鸢尾素对皮瓣缺血再灌注的有益作用鲜有报道。本研究旨在确定鸢尾素在皮瓣移植中是否发挥保护作用，并找出影响血清鸢尾素水平的因素。
我们分析了40例行皮瓣移植患者手术前后血清鸢尾素水平和皮瓣血流量的变化。通过代谢参数测量分析影响血清鸢尾素水平的因素。
术前血清鸢尾素水平与术后7天皮瓣血流量呈正相关。术后前3天血清鸢尾素水平的升高与皮瓣血流量呈正相关。高强度运动持续时间较长、骨骼肌含量较高、体重指数较低和腰臀比与鸢尾素水平较高有关。空腹血糖和糖化血红蛋白水平与血清鸢尾素水平呈显著负相关。包括性别在内的其他几个指标与血清鸢尾素水平无关。
血清鸢尾素水平有利于皮瓣移植过程中的血流恢复。通过调整运动的时间和强度以及控制患者的体型，可能会取得更好的效果。
