Norouzi Fatemeh, Aghajani Sanaz, Vosoughi Nasim, Sharif Shiva, Ghahremanzadeh Kazem, Mokhtari Zeinab, Verdi Javad
Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pathology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Regen Ther. 2024 Nov 19;26:1124-1137. doi: 10.1016/j.reth.2024.10.001. eCollection 2024 Jun.
The skin covers the surface of the body and acts as the first defense barrier against environmental damage. Exposure of the skin to environmental physical and chemical factors such as mechanical injuries, UV rays, air pollution, chemicals, etc. Leads to numerous damages to skin cells such as fibroblasts, keratinocytes, melanocytes, etc. The harmful effects of environmental factors on skin cells could lead to various skin diseases, chronic wounds, wrinkles, and skin aging. Hair is an essential part of the body, serving multiple functions such as regulating body temperature and protecting against external factors like dust (through eyelashes and eyebrows). It also reflects an individual's personality. Therefore, the need for new treatment methods for skin diseases and lesions and at the same time preserving the youth, freshness, and beauty of the skin has been highly noticed by experts. Exosomes are nanovesicles derived from cells that contain various biological compounds such as lipids, proteins, nucleic acids, and carbohydrates. They are secreted by a variety of mammalian cells and even different plants. Exosomes are of great interest as a new therapeutic approach due to their stability, ability to be transported throughout the body, paracrine and endocrine effects, as well as the ability to carry various compounds and drugs to target cells.
In this review, we have discussed the characteristics of exosomes, their cellular sources, and their therapeutic effects on wrinkles, skin aging, and rejuvenation and hair regrowth.
皮肤覆盖身体表面，作为抵御环境损伤的第一道防御屏障。皮肤暴露于环境物理和化学因素，如机械损伤、紫外线、空气污染、化学物质等，会导致皮肤细胞如成纤维细胞、角质形成细胞、黑素细胞等受到多种损伤。环境因素对皮肤细胞的有害影响可能导致各种皮肤疾病、慢性伤口、皱纹和皮肤衰老。毛发是身体的重要组成部分，具有多种功能，如调节体温和抵御灰尘等外部因素（通过睫毛和眉毛）。它还反映个人性格。因此，专家们高度关注针对皮肤疾病和损伤的新治疗方法，同时保持皮肤的年轻、清新和美丽。外泌体是源自细胞的纳米囊泡，含有脂质、蛋白质、核酸和碳水化合物等多种生物化合物。它们由多种哺乳动物细胞甚至不同植物分泌。外泌体作为一种新的治疗方法备受关注，因为它们具有稳定性、能够在全身运输、旁分泌和内分泌作用，以及将各种化合物和药物输送到靶细胞的能力。
在本综述中，我们讨论了外泌体的特征、其细胞来源以及它们对皱纹、皮肤衰老、年轻化和毛发再生的治疗作用。
