间充质干细胞衍生外泌体在治疗雄激素性脱发中的潜力。
Potential of mesenchymal stem cell-derived exosomes in the treatment of androgenetic alopecia.
作者信息
Rajendran Ramya Lakshmi, Ahn Byeong-Cheol, Gangadaran Prakash
机构信息
BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu 41944, South Korea.
Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, South Korea.
出版信息
World J Stem Cells. 2025 May 26;17(5):107078. doi: 10.4252/wjsc.v17.i5.107078.
Exosomes are derived from various cell types, including mesenchymal stem cells (MSCs), and play a crucial role in cellular communication, significantly influencing tissue repair and regeneration and facilitating the healing process. Thus, insights into the functions of exosomes present novel opportunities in regenerative therapy. This article aims to discuss the promising potential of exosomes derived from human adipose-derived MSCs in treating androgenetic alopecia. This study aims to highlight how exosomes derived from human adipose-derived MSCs enhance dermal papilla cell proliferation through the Wnt/β-catenin pathway, counteracting the effects of excessive dihydrotestosterone and offering a novel approach for treating androgenetic alopecia.
外泌体来源于包括间充质干细胞（MSC）在内的多种细胞类型，在细胞通讯中发挥关键作用，对组织修复和再生有显著影响，并促进愈合过程。因此，对外泌体功能的深入了解为再生治疗带来了新机遇。本文旨在探讨源自人脂肪来源间充质干细胞的外泌体在治疗雄激素性脱发方面的潜在应用前景。本研究旨在强调源自人脂肪来源间充质干细胞的外泌体如何通过Wnt/β-连环蛋白信号通路增强毛乳头细胞增殖，抵消过量双氢睾酮的影响，从而为治疗雄激素性脱发提供一种新方法。
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