Haykal Diala, Wyles Saranya, Garibyan Lilit, Cartier Hugues, Gold Michael
J Drugs Dermatol. 2025 Jan 1;24(1):12-18. doi: 10.36849/JDD.8872.
Exosomes are small extracellular vesicles (30-150 nm in size) that play a critical role in cellular communication, transporting proteins, lipids, and nucleic acids between cells. This literature review focuses on evaluating the potential benefits and limitations of exosomes in enhancing skin health and aesthetics through indications such as skin rejuvenation, hair restoration, and pigmentation disorders.
A thorough literature search was conducted on PubMed using specific MeSH, including "exosomes," "aesthetics," "cosmetic dermatology," "skin rejuvenation," "hair growth," and "wrinkle reduction." The search was limited to free-access studies published in various countries within the last ten years (2014-2024). As a result, a total of 56 relevant references were identified and reviewed to support the discussion.
There are currently no US Food and Drug Administration (FDA) approved exosomes. This review highlights exosomes' potential in skin rejuvenation through extracellular matrix production and matrix metalloproteinases (MMP) inhibition, as well as in hair restoration by stimulating follicle cell activity and modulating inflammation. Despite these benefits, challenges remain, including inconsistent isolation methods, source variability, and the need for clinical trials to confirm long-term safety and efficacy. The regulatory landscape is evolving, and further research is essential to meet standards before exosomes can be broadly adopted in cosmetic dermatology.
While exosomes hold significant potential for non-invasive cosmetic dermatology, there are challenges that need to be addressed, including the standardization of exosome isolation and characterization, the establishment of safety profiles, and the conduct of extensive clinical trials. J Drugs Dermatol. 2025;24(1):12-18. doi:10.36849/JDD.8872.
外泌体是小型细胞外囊泡（大小为30 - 150纳米），在细胞间通讯中发挥关键作用，可在细胞间运输蛋白质、脂质和核酸。本综述聚焦于评估外泌体通过皮肤年轻化、毛发再生和色素沉着紊乱等适应症在促进皮肤健康和美容方面的潜在益处及局限性。
在PubMed上使用特定医学主题词（MeSH）进行全面文献检索，包括“外泌体”“美学”“美容皮肤病学”“皮肤年轻化”“毛发生长”和“减少皱纹”。检索限于过去十年（2014 - 2024年）在各国发表的可免费获取的研究。结果，共鉴定并综述了56篇相关参考文献以支持讨论。
目前美国食品药品监督管理局（FDA）尚未批准外泌体。本综述强调了外泌体在通过细胞外基质生成和基质金属蛋白酶（MMP）抑制实现皮肤年轻化方面的潜力，以及通过刺激毛囊细胞活性和调节炎症实现毛发再生的潜力。尽管有这些益处，但挑战依然存在，包括分离方法不一致、来源变异性以及需要进行临床试验以确认长期安全性和有效性。监管环境在不断演变，在广泛应用于美容皮肤病学之前，还需要进一步研究以达到标准。
虽然外泌体在非侵入性美容皮肤病学方面具有巨大潜力，但仍有一些挑战需要解决，包括外泌体分离和表征的标准化、安全性概况的建立以及广泛的临床试验的开展。《药物皮肤病学杂志》。2025年；24(1):12 - 18。doi:10.36849/JDD.8872。
