Kostulas V K, Henriksson A, Link H
Arch Neurol. 1986 May;43(5):447-51. doi: 10.1001/archneur.1986.00520050027016.
Of 53 patients with monosymptomatic paresthesiae, 55% had oligoclonal bands and 28% an elevated cerebrospinal fluid (CSF) IgG index. Over a mean observation period of 64 months, nine patients developed clinically definite multiple sclerosis (MS); all of these patients had IgG bands, illustrating the prognostic importance of this CSF aberration. Two lumbar punctures more than one year apart were performed in 31 of the patients, of whom 20 had oligoclonal bands. This abnormality was constant between the time of punctures in all subjects except one, thus behaving as in MS. Similarly, the CSF findings in the 11 patients without oligoclonal bands remained normal over the observation period. The majority of patients with oligoclonal bands had cells in their CSF producing immunoglobulin of one or more of the three main classes, while none of those without oligoclonal bands displayed immunoglobulin-producing cells in CSF. Occurrence of oligoclonal bands in CSF is common in patients with paresthesiae and increases the risk for future development of MS.
在53例单症状感觉异常患者中，55%有寡克隆带，28%脑脊液（CSF）IgG指数升高。在平均64个月的观察期内，9例患者发展为临床确诊的多发性硬化症（MS）；所有这些患者都有IgG带，说明了这种脑脊液异常的预后重要性。31例患者进行了间隔一年以上的两次腰椎穿刺，其中20例有寡克隆带。除1例患者外，所有受试者穿刺时这种异常情况均持续存在，表现与MS相同。同样，11例无寡克隆带患者的脑脊液检查结果在观察期内保持正常。大多数有寡克隆带的患者脑脊液中有产生三种主要免疫球蛋白类别中一种或多种的细胞，而无寡克隆带的患者脑脊液中均未显示产生免疫球蛋白的细胞。脑脊液中出现寡克隆带在感觉异常患者中很常见，且增加了未来发生MS的风险。
