Stendahl-Brodin L, Link H
Acta Neurol Scand. 1983 May;67(5):301-4. doi: 10.1111/j.1600-0404.1983.tb04579.x.
In 1974 we examined 30 patients 0.5-14 (mean 5) years after acute unilateral optic neuritis (ON), when no clinical signs of multiple sclerosis (MS) were discernible. 11 of the patients had oligoclonal bands in the cerebrospinal fluid (CSF). Re-examination after an additional 6 years revealed that 9 of the 11 ON patients with oligoclonal bands (but only 1 of the 19 without this CSF abnormality) had developed MS. The occurrence of oligoclonal bands in CSF in a patient with ON is--within the limits of the present observation time--accompanied by a significantly increased risk of the future development of MS. Recurrent ON also occurred significantly more often in those ON patients who later developed MS.
1974年，我们对30例急性单侧视神经炎（ON）患者进行了检查，时间为发病后0.5 - 14岁（平均5岁），此时尚无多发性硬化症（MS）的临床体征。11例患者脑脊液（CSF）中有寡克隆带。再过6年后复查发现，11例有寡克隆带的视神经炎患者中有9例（但19例无脑脊液异常的患者中只有1例）发展为多发性硬化症。在视神经炎患者中，脑脊液中出现寡克隆带——在目前观察时间范围内——伴随着未来发生多发性硬化症的风险显著增加。后来发展为多发性硬化症的视神经炎患者中，复发性视神经炎的发生频率也明显更高。
