不仅仅是垃圾车：禁区衰退在斑马鱼胚胎发育过程中发挥作用。
Not just a garbage truck: No-go decay plays a role during embryo development in zebrafish.
作者信息
Plastrik Alana R, Zaher Hani S
机构信息
Department of Biology, Washington University in St. Louis, St. Louis, Missouri, United States of America.
出版信息
PLoS Biol. 2024 Dec 6;22(12):e3002925. doi: 10.1371/journal.pbio.3002925. eCollection 2024 Dec.
Abstract
In eukaryotes, defective mRNAs that impede the movement of the ribosome are subject to rapid decay via no-go decay (NGD). In this issue of PLOS Biology, Ishibashi and colleagues expand on the role of NGD and reveal new endogenous targets for the process in zebrafish.
摘要
在真核生物中，阻碍核糖体移动的缺陷型信使核糖核酸（mRNA）会通过无义介导的mRNA降解（NGD）迅速降解。在本期《公共科学图书馆·生物学》中，石桥及其同事拓展了NGD的作用，并揭示了斑马鱼中该过程的新内源性靶点。
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