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Sphingosine Kinase 1 - A Therapeutic Opportunity for Alleviating Liver Fibrosis?

作者信息

Teo Jia Ming Nickolas, Ling Guang Sheng

机构信息

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong.

出版信息

Cell Mol Gastroenterol Hepatol. 2025;19(2):101430. doi: 10.1016/j.jcmgh.2024.101430. Epub 2024 Dec 3.

DOI:10.1016/j.jcmgh.2024.101430
PMID:39642919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11785568/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4a7/11785568/c9c52d932bf1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4a7/11785568/c9c52d932bf1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4a7/11785568/c9c52d932bf1/gr1.jpg

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1
Sphingosine Kinase 1 - A Therapeutic Opportunity for Alleviating Liver Fibrosis?鞘氨醇激酶1——缓解肝纤维化的治疗契机？
Cell Mol Gastroenterol Hepatol. 2025;19(2):101430. doi: 10.1016/j.jcmgh.2024.101430. Epub 2024 Dec 3.
2
Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis.鞘氨醇激酶/鞘氨醇 1-磷酸（S1P）/S1P 受体轴参与肝纤维化相关的血管生成。
J Hepatol. 2013 Jul;59(1):114-23. doi: 10.1016/j.jhep.2013.02.021. Epub 2013 Mar 4.
3
Leucine-rich Repeats and Immunoglobulin 1 (LRIG1) Ameliorates Liver Fibrosis and Hepatic Stellate Cell Activation via Inhibiting Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P) Pathway.富含亮氨酸重复序列和免疫球蛋白 1（LRIG1）通过抑制鞘氨醇激酶 1（SphK1）/鞘氨醇-1-磷酸（S1P）通路改善肝纤维化和肝星状细胞活化。
Iran J Allergy Asthma Immunol. 2020 Aug 25;19(4):397-408. doi: 10.18502/ijaai.v19i4.4114.
4
Hepatopoietin Cn reduces ethanol-induced hepatoxicity via sphingosine kinase 1 and sphingosine 1-phosphate receptors.肝生素 Cn 通过鞘氨醇激酶 1 和鞘氨醇 1-磷酸受体减少乙醇诱导的肝毒性。
J Pathol. 2013 Aug;230(4):365-76. doi: 10.1002/path.4194.
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Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.1-磷酸鞘氨醇可防止造血干细胞从肝脏流出以减轻纤维化。
Gastroenterology. 2017 Jul;153(1):233-248.e16. doi: 10.1053/j.gastro.2017.03.022. Epub 2017 Mar 28.
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Generation of sphingosine-1-phosphate by sphingosine kinase 1 protects nonalcoholic fatty liver from ischemia/reperfusion injury through alleviating reactive oxygen species production in hepatocytes.鞘氨醇激酶 1 通过产生鞘氨醇-1-磷酸来减轻肝细胞内活性氧的产生，从而保护非酒精性脂肪肝免受缺血/再灌注损伤。
Free Radic Biol Med. 2020 Nov 1;159:136-149. doi: 10.1016/j.freeradbiomed.2020.07.004. Epub 2020 Jul 30.
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Integrative roles of sphingosine kinase in liver pathophysiology.鞘氨醇激酶在肝脏病理生理学中的综合作用
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Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology.肝脏病理生物学中的鞘氨醇激酶与1-磷酸鞘氨醇
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Sphingosine-1-phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy.鞘氨醇-1-磷酸促进充血性肝病小鼠模型中的肿瘤发生和肝纤维化。
Hepatology. 2022 Jul;76(1):112-125. doi: 10.1002/hep.32256. Epub 2021 Dec 22.
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Transforming growth factor-β-sphingosine kinase 1/S1P signaling upregulates microRNA-21 to promote fibrosis in renal tubular epithelial cells.转化生长因子-β-鞘氨醇激酶1/鞘氨醇-1-磷酸信号上调微小RNA-21以促进肾小管上皮细胞纤维化。
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本文引用的文献

1
Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and Polarization.鞘氨醇激酶 1 通过介导巨噬细胞募集和极化加重肝纤维化。
Cell Mol Gastroenterol Hepatol. 2024;18(6):101406. doi: 10.1016/j.jcmgh.2024.101406. Epub 2024 Sep 19.
2
Current status and future trends of the global burden of MASLD.全球 MASLD 负担的现状和未来趋势。
Trends Endocrinol Metab. 2024 Aug;35(8):697-707. doi: 10.1016/j.tem.2024.02.007. Epub 2024 Feb 29.
3
Treatment of liver fibrosis: Past, current, and future.肝纤维化的治疗：过去、现在与未来
World J Hepatol. 2023 Jun 27;15(6):755-774. doi: 10.4254/wjh.v15.i6.755.
4
Macrophage in liver Fibrosis: Identities and mechanisms.肝纤维化中的巨噬细胞：特性与机制。
Int Immunopharmacol. 2023 Jul;120:110357. doi: 10.1016/j.intimp.2023.110357. Epub 2023 May 22.
5
The versatility of macrophage heterogeneity in liver fibrosis.巨噬细胞异质性在肝纤维化中的多功能性。
Front Immunol. 2022 Aug 5;13:968879. doi: 10.3389/fimmu.2022.968879. eCollection 2022.
6
Macrophage Polarization and Its Role in Liver Disease.巨噬细胞极化及其在肝脏疾病中的作用。
Front Immunol. 2021 Dec 14;12:803037. doi: 10.3389/fimmu.2021.803037. eCollection 2021.
7
Safety profile of autologous macrophage therapy for liver cirrhosis.自体巨噬细胞疗法治疗肝硬化的安全性。
Nat Med. 2019 Oct;25(10):1560-1565. doi: 10.1038/s41591-019-0599-8. Epub 2019 Oct 7.
8
Prevalence of Alcoholic Fatty Liver Disease Among Adults in the United States, 2001-2016.美国成年人酒精性脂肪肝疾病的患病率，2001-2016 年。
JAMA. 2019 May 7;321(17):1723-1725. doi: 10.1001/jama.2019.2276.
9
Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2.鞘氨醇激酶 1 通过防止 miR-19b-3p 介导的 CCR2 抑制来促进肝纤维化。
Hepatology. 2018 Sep;68(3):1070-1086. doi: 10.1002/hep.29885. Epub 2018 Apr 27.
10
Liver fibrosis.肝纤维化
J Clin Invest. 2005 Feb;115(2):209-18. doi: 10.1172/JCI24282.