Gawęda Magdalena, Marchewka Jakub, Jeleń Piotr, Bik Maciej, Sowa Maciej, Simka Wojciech, Zagrajczuk Barbara, Kucia Zofia, Zając Patryk, Sitarz Maciej
NOMATEN CoE, NOMATEN MAB, National Centre for Nuclear Research, A. Soltana 7 Str., 05-400 Otwock, Poland.
Faculty of Materials Science and Ceramics, AGH University of Krakow, A. Mickiewicza 30 Av, 30-059 Kraków, Poland.
ACS Appl Mater Interfaces. 2024 Dec 18;16(50):68836-68849. doi: 10.1021/acsami.4c13292. Epub 2024 Dec 6.
This article presents a study on the functional properties and morphology of coatings based on amorphous silicon oxycarbide modified with phosphate ions and comodified with aluminum and boron. The objective of this modification was to enhance the biocompatibility and bioactivity without affecting its protective properties. The comodification was aimed toward stabilization of phosphate in the structure. The coatings were prepared according to the typical procedure for polymer-derived ceramics: synthesized via the sol-gel method, deposited using the dip-coating technique, and subsequently pyrolyzed. Comprehensive analyses of the morphology, surface properties, corrosion resistance, and bioactivity were conducted to assess their functional performance. The coatings exhibited uniform and smooth surfaces, with phase separation observed in the boron-modified SiOC series. Surface wettability and free energy measurements demonstrated that SiOC and SiOC coatings possessed moderate hydrophilicity and favorable surface free energy for cell adhesion and bone tissue mineralization. Corrosion resistance tests in Ringer's solution revealed that SiOC coatings provided the highest protection against ion leaching, while SiOC showed decreased resistance due to surface cracks. Bioactivity tests indicated calcium phosphate precipitation on the surface of all samples with higher hydroxyapatite formation on SiOC and SiOC coatings. In vitro tests using MG-63 osteoblast-like cells confirmed the biocompatibility of the coatings, with SiOC and SiOC exhibiting the best combination of bioactivity, cell adhesion, and proliferation. These findings suggest that the phosphate- and boron-modified SiOC-based coatings are promising candidates for enhancing bone integration in orthopedic implants.
本文介绍了一项关于基于磷酸根离子改性并与铝和硼共改性的非晶态碳氧化硅涂层的功能特性和形态的研究。这种改性的目的是在不影响其保护性能的情况下提高生物相容性和生物活性。共改性旨在使结构中的磷酸盐稳定化。涂层按照聚合物衍生陶瓷的典型工艺制备：通过溶胶 - 凝胶法合成，采用浸涂技术沉积，随后进行热解。对涂层的形态、表面性质、耐腐蚀性和生物活性进行了全面分析，以评估其功能性能。涂层呈现出均匀光滑的表面，在硼改性的SiOC系列中观察到相分离。表面润湿性和自由能测量表明，SiOC和SiOC涂层具有适度的亲水性以及有利于细胞粘附和骨组织矿化的表面自由能。在林格氏溶液中的耐腐蚀性测试表明，SiOC涂层对离子浸出提供了最高的保护，而SiOC由于表面裂纹导致耐腐蚀性下降。生物活性测试表明，所有样品表面均有磷酸钙沉淀，在SiOC和SiOC涂层上形成的羟基磷灰石更多。使用MG - 63成骨样细胞的体外测试证实了涂层的生物相容性，SiOC和SiOC在生物活性、细胞粘附和增殖方面表现出最佳组合。这些发现表明，基于磷酸盐和硼改性的SiOC涂层有望成为增强骨科植入物骨整合的候选材料。
