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在专科门诊姑息治疗背景下使用抗生素管理措施是否合理且可行?一项基于访谈的研究。

Is the use of antibiotic stewardship measures in the context of specialized outpatient palliative care sensible and feasible? An interview-based study.

作者信息

Kaiser Ulrich, Kaiser Florian, Schmidt Jörg, Vehling-Kaiser Ursula, Hitzenbichler Florian

机构信息

Clinic and Polyclinic for Internal Medicine III, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

MVZ Dr. Vehling-Kaiser GmbH, Landshut, Germany.

出版信息

BMC Palliat Care. 2024 Dec 7;23(1):280. doi: 10.1186/s12904-024-01609-x.

DOI:10.1186/s12904-024-01609-x
PMID:39643906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11624597/
Abstract

BACKGROUND

Specialized outpatient palliative care (SAPV) is a component of palliative care in Germany, which assists approximately 10% of palliative patients. The majority of these patients have a malignant disease and are at increased risk of complications or severe infection. Antibiotic stewardship (ABS) measures are implemented to optimize antibiotic administration; however, there is little data available in this area, particularly for SAPV. Therefore, we examined the extent to which ABS measures can be meaningfully used or implemented in SAPV.

METHODS

After establishing a corresponding interview guide, 15 experts from specialized areas were interviewed on this subject by the Institute for Market Research in Healthcare Munich (IMIG) through audio-registered individual interviews. The interviews were analyzed using the qualitative content analysis method according to Mayring.

RESULTS

All 15 experts participated. The primary benefits cited were greater safety in the prescription and decision-making process for antibiotics in the areas of SAPV and improved quality of life. The implementation of continuous ABS measures for SAPV was considered difficult in some cases and linked to certain prerequisites, such as supportive advice from existing systems. The possibility of further training for SAPV members in the area of ABS was considered particularly advantageous.

CONCLUSIONS

The implementation of ABS measures in SAPV is feasible in principle; however, it is difficult to implement under the current conditions. Close cooperation with an existing external ABS expert/team will be helpful. This will provide more security for a small, but relevant proportion of SAPV patients, and for the SAPV team treating them.

摘要

背景

专科门诊姑息治疗(SAPV)是德国姑息治疗的一个组成部分,为约10%的姑息治疗患者提供帮助。这些患者中的大多数患有恶性疾病,并发症或严重感染风险增加。实施抗生素管理(ABS)措施以优化抗生素使用;然而,该领域的数据很少,尤其是关于SAPV的数据。因此,我们研究了ABS措施在SAPV中能够在多大程度上得到有意义的应用或实施。

方法

在制定相应的访谈指南后,慕尼黑医疗保健市场研究所(IMIG)通过音频记录的个人访谈就该主题采访了15位专业领域的专家。采用根据迈林的定性内容分析法对访谈进行分析。

结果

15位专家全部参与。提到的主要益处包括在SAPV领域抗生素处方和决策过程中的更高安全性以及生活质量的提高。在某些情况下,为SAPV实施持续的ABS措施被认为是困难的,并且与某些先决条件相关,例如现有系统的支持性建议。在ABS领域为SAPV成员提供进一步培训的可能性被认为特别有利。

结论

在SAPV中实施ABS措施原则上是可行的;然而,在当前条件下难以实施。与现有的外部ABS专家/团队密切合作将有所帮助。这将为一小部分但相关的SAPV患者及其治疗的SAPV团队提供更多保障。

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Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study.抗生素治疗与老年晚期癌症患者的药物不良事件有关:一项队列研究。
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Factors That Influence the Prescription of Antibiotic Therapy at the End-of-Life: Construction and Validation of a Scale.
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Cureus. 2022 Nov 20;14(11):e31689. doi: 10.7759/cureus.31689. eCollection 2022 Nov.
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The impact of palliative care consultation on reducing antibiotic overuse in hospitalized patients with terminal cancer at the end of life: a propensity score-weighting study.姑息治疗会诊对减少晚期癌症住院患者临终时抗生素过度使用的影响:一项倾向评分加权研究。
J Antimicrob Chemother. 2022 Dec 23;78(1):302-308. doi: 10.1093/jac/dkac405.
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