Means L W, Gray S L, Medlin C W
Alcohol. 1986 Jan-Feb;3(1):1-4. doi: 10.1016/0741-8329(86)90062-5.
Three groups of male Long-Evans rats, that were the offspring of dams maintained throughout pregnancy on a liquid diet in which 35% of the calories were derived from ethanol, pair fed an isocaloric liquid diet that had maltose-dextrin substituted for the ethanol, or maintained on lab chow and water were used as subjects. All subjects were nursed by foster mothers maintained on lab chow and water throughout pregnancy and lactation. The groups were not found to differ on open field activity or number of approaches to four stimulus objects in an open field at 26-30 days of age, on spontaneous alternation at 50-55 days of age or on response to a novel alley at 55 days of age. It was concluded that in the rat, prenatal ethanol exposure does not result in demonstrable changes in responsivity to stimuli in rats tested after 26 days of age.
选取三组雄性Long-Evans大鼠作为研究对象，其中一组大鼠的母鼠在整个孕期都喂食液体饲料，该饲料中35%的热量来自乙醇；另一组大鼠的母鼠成对喂食等热量的液体饲料，该饲料用麦芽糖糊精替代了乙醇；第三组大鼠的母鼠则喂食实验室标准饲料并饮水。所有受试大鼠在整个怀孕和哺乳期均由喂食实验室标准饲料并饮水的代孕母鼠哺育。研究发现，在26至30日龄时，三组大鼠在旷场活动、接近旷场中四个刺激物体的次数方面没有差异；在50至55日龄时，自发交替行为方面没有差异；在55日龄时，对新通道的反应方面也没有差异。研究得出结论，在大鼠中，产前乙醇暴露不会导致26日龄后测试的大鼠对刺激的反应出现明显变化。
