苯妥英、卡马西平和丙戊酸钠的戒断症状。
Withdrawal symptoms from phenytoin, carbamazepine and sodium valproate.
作者信息
Duncan J S, Shorvon S D, Trimble M R
机构信息
Institute of Neurology, National Hospital, London, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1988 Jul;51(7):924-8. doi: 10.1136/jnnp.51.7.924.
Abstract
A prospective, double-blind, placebo-controlled investigation of possible withdrawal symptoms from phenytoin, carbamazepine and sodium valproate is reported in patients with active epilepsy, on combination therapy. There was an increase in seizures on reduction and withdrawal of carbamazepine, but there was no convincing evidence of withdrawal symptoms from any of these drugs.
摘要
本文报道了一项针对正在接受联合治疗的活动性癫痫患者，对苯妥英钠、卡马西平和丙戊酸钠可能出现的撤药症状进行的前瞻性、双盲、安慰剂对照研究。在减少和停用卡马西平后癫痫发作有所增加，但没有令人信服的证据表明这些药物中的任何一种会出现撤药症状。
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