Jiang Liya, Chen Fei, He Meiyang, Zhou Yuejie, Wei Qingqian, Hu Jintian
Department of Cosmetic Injection Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
The First Clinical College, Guangzhou Medical University, Guangzhou, China.
J Cosmet Dermatol. 2025 Feb;24(2):e16681. doi: 10.1111/jocd.16681. Epub 2024 Dec 8.
Soft tissue filler injection is the second most commonly performed cosmetic procedure worldwide, with augmentation rhinoplasty being the most common filling surgery in Asian countries because Asians predominantly have a low nasal bridge. With the increasing pursuit of beauty, the adverse reactions after injection not only damage the patient's appearance but also greatly affect their quality of life. Therefore, exploring effective methods to address adverse reactions after nasal filler injections is necessary.
Herein, we aimed to explore safe and effective drug doses and concentrations for the treatment of two patients who developed an allergic reaction after a nasal filling by intralesional drug injection.
Two patients developed severe swelling and deformity of the nose after the injection of fillers 6 months to 1 year prior to presentation. High-frequency ultrasound and local conditions revealed inflammation in the injected area. The patients were administered the combination of 0.7% triamcinolone acetonide, 0.42% 5-fluorouracil, and 0.7% lidocaine into the affected area; they were followed up for 6 months.
After three times of treatment, swelling and sclerosis disappeared after 44.5 ± 2.12 days. No adverse effects of the infections were observed.
This drug regimen may represent a safe and effective therapeutic strategy for the treatment of complications after soft tissue filler injections.
软组织填充剂注射是全球第二常见的美容手术，隆鼻术是亚洲国家最常见的填充手术，因为亚洲人大多鼻梁较低。随着对美的追求日益增加，注射后的不良反应不仅损害患者的容貌，还极大地影响他们的生活质量。因此，探索解决鼻部填充剂注射后不良反应的有效方法很有必要。
在此，我们旨在探索安全有效的药物剂量和浓度，用于治疗两名在隆鼻填充后发生过敏反应的患者，通过病灶内药物注射进行治疗。
两名患者在就诊前6个月至1年注射填充剂后出现严重的鼻部肿胀和畸形。高频超声和局部情况显示注射区域有炎症。向患区注射0.7%曲安奈德、0.42% 5-氟尿嘧啶和0.7%利多卡因的组合；对他们进行了6个月的随访。
经过三次治疗，肿胀和硬结在44.5±2.12天后消失。未观察到感染的不良反应。
这种药物方案可能是治疗软组织填充剂注射后并发症的一种安全有效的治疗策略。
