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硬膜外镇痛下引产的液体疗法:对母婴的生化影响

Fluid therapy for induced labour under epidural analgesia: biochemical consequences for mother and infant.

作者信息

Evans S E, Crawford J S, Stevens I D, Durbin G M, Daya H

出版信息

Br J Obstet Gynaecol. 1986 Apr;93(4):329-33.

PMID:3964608
Abstract

Two types of fluid regimen were provided for patients having labour induced under epidural analgesia. Reasons for the infusion were to pre-load the circulation before the epidural, and subsequently to sustain maternal hydration. Both fluids were isotonic, one was predominantly saline based (Hartmann's solution) and the other contained both saline and dextrose. Blood glucose and serum sodium, lactate and beta-hydroxybutyrate were measured before the start of induction, at delivery and in the cord sample. Blood glucose and serum sodium were measured in the babies at 12 and 24 h of age. The dextrose-saline fluid caused small but significant changes in blood glucose and serum sodium which did not exceed the normal reference limits for either. The use of Hartmann's solution was associated with considerable rises in maternal serum beta-hydroxybutyrate at delivery. Neither fluid had any significant effect on the blood glucose or serum sodium in infants at 12 and 24 h of age.

摘要

为接受硬膜外镇痛引产的患者提供了两种液体输注方案。输液的目的是在硬膜外麻醉前对循环系统进行预负荷,并在随后维持产妇的水合作用。两种液体均为等渗液,一种主要以生理盐水为基础(哈特曼氏溶液),另一种含有生理盐水和葡萄糖。在引产开始前、分娩时以及采集脐带血样本时测量血糖、血清钠、乳酸和β-羟基丁酸。在婴儿出生后12小时和24小时测量其血糖和血清钠。葡萄糖生理盐水导致血糖和血清钠出现微小但显著的变化,但均未超过各自的正常参考范围。使用哈特曼氏溶液与分娩时产妇血清β-羟基丁酸显著升高有关。两种液体对12小时和24小时龄婴儿的血糖或血清钠均无显著影响。

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Fluid therapy for induced labour under epidural analgesia: biochemical consequences for mother and infant.硬膜外镇痛下引产的液体疗法:对母婴的生化影响
Br J Obstet Gynaecol. 1986 Apr;93(4):329-33.
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Continuous maternal glucose infusion during labor: effects on maternal and fetal glucose and lactate levels.分娩期间持续输注母体葡萄糖:对母体和胎儿葡萄糖及乳酸水平的影响。
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[Important metabolic parameters in the peripartum period as affected by peridural anesthesia].
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Concentrations of lactate and pyruvate in maternal and neonatal blood with different intravenous fluids used for prehydration before epidural anesthesia.硬膜外麻醉前用于预水化的不同静脉输液情况下母婴血液中乳酸和丙酮酸的浓度。
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引用本文的文献

1
Prophylactic intravenous preloading for regional analgesia in labour.分娩时区域镇痛的预防性静脉预负荷
Cochrane Database Syst Rev. 2004 Oct 18;2004(4):CD000175. doi: 10.1002/14651858.CD000175.pub2.