Chen Yan, Dai Jing, Chen Peng, Dai Quan, Chen Ya, Li Yuying, Lu Man, Qin Shugang, Wang Qiuju
Department of Pharmacy, Center for Translational Research in Cancer, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China; Department of Respiratory Critical Care, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
School of pharmacy, Chengdu Medical college, Chengdu, China.
Pharmacol Res. 2024 Dec;210:107539. doi: 10.1016/j.phrs.2024.107539. Epub 2024 Dec 6.
Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of cancer pathogenesis, influencing various cellular processes and contributing to tumorigenesis. Sphingolipid metabolism has garnered interest as a potential target for cancer therapy owing to its considerable diagnostic and prognostic value. Recent studies have demonstrated that lncRNAs regulate tumor-associated metabolic reprogramming via sphingolipid metabolism. However, the precise nature of the interactions between lncRNAs and sphingolipid metabolism remains unclear. This review summarizes the key roles of lncRNAs and sphingolipid metabolism in tumorigenesis. We emphasize that the interaction between lncRNAs and sphingolipid metabolism influences their impact on both cancer prognosis and drug resistance. These findings suggest that lncRNA-sphingolipid metabolism interaction holds great potential as a newl target for cancer treatment.
长链非编码RNA（lncRNAs）已成为癌症发病机制的关键调节因子，影响各种细胞过程并促进肿瘤发生。由于鞘脂代谢具有相当大的诊断和预后价值，其作为癌症治疗的潜在靶点已引起关注。最近的研究表明，lncRNAs通过鞘脂代谢调节肿瘤相关的代谢重编程。然而，lncRNAs与鞘脂代谢之间相互作用的确切性质仍不清楚。本综述总结了lncRNAs和鞘脂代谢在肿瘤发生中的关键作用。我们强调，lncRNAs与鞘脂代谢之间的相互作用会影响它们对癌症预后和耐药性的影响。这些发现表明，lncRNA-鞘脂代谢相互作用作为癌症治疗的新靶点具有巨大潜力。
