Xu Chao, Pei Yuanmin, Wang Yanli, Li Wenpeng, Yang Liu, Chai Aimei, Wang Ying, Fan Wenrong, Tan Huiquan
Department of Plastic Surgery, Zibo Central Hospital, Zibo, China.
Yidu Central Hosptial, Weifang, China.
J Biomater Appl. 2025 Mar;39(8):819-827. doi: 10.1177/08853282241305362. Epub 2024 Dec 8.
Auto-concentrated growth factor (CGF) constitutes the latest generation of plasma extract, and has high concentrations of growth factors and white blood cells. Due to the continuous variable speed centrifugation used during preparation, the tensile strength of the fibrin is also higher. CGF preparation does not involve the use of animal serum, minimizing the risk of infection and immune rejection. Therefore, it has wide potential applications in various fields of regenerative medicine. This paper summarizes the history behind CGF development, reviews the clinical applications and research progress concerning single CGF therapy and CGF used in combination with other treatments in multiple wound repair, and summarizes its potential value as therapeutic agent. Finally, some constructive suggestions and research perspectives for the application of CGF in wound healing are put forward. The available evidence indicates that CGF can promote the healing of chronic refractory wounds and acute wound, promote the growth of granulation, accelerate the speed and improve the quality of wound healing, reduce scar formation, minimize the need for repeated wound dressing, and ameliorate the pain experienced by patients.
自体浓缩生长因子（CGF）是最新一代的血浆提取物，含有高浓度的生长因子和白细胞。由于制备过程中采用连续变速离心，纤维蛋白的拉伸强度也更高。CGF制备不涉及动物血清的使用，将感染和免疫排斥风险降至最低。因此，它在再生医学的各个领域具有广泛的潜在应用。本文总结了CGF发展背后的历史，回顾了单一CGF疗法以及CGF与其他治疗方法联合用于多种伤口修复的临床应用和研究进展，并总结了其作为治疗剂的潜在价值。最后，对CGF在伤口愈合中的应用提出了一些建设性建议和研究展望。现有证据表明，CGF可促进慢性难治性伤口和急性伤口的愈合，促进肉芽生长，加快伤口愈合速度并提高愈合质量，减少瘢痕形成，减少伤口重复换药的需求，并减轻患者的疼痛。
