Lin Shichao, Cheng Yuan, Zhang He, Wang Xiaoyu, Zhang Yuye, Zhang Yuanjian, Miao Leiying, Zhao Xiaozhi, Wei Hui
Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu, 210093, China.
Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210093, China.
Small. 2020 Jul;16(27):e1902123. doi: 10.1002/smll.201902123. Epub 2019 Aug 29.
The global tobacco epidemic is still a devastating threat to public health. Toxic reactive oxygen species (ROS) in the cigarette smoke cannot be efficiently eliminated by currently available cigarette filters. The resultant oxidative stress causes severe lung injury and further diseases. To tackle this challenge, herein, a novel copper tannic acid coordination (CuTA) nanozyme is reported as a highly active and thermostable ROS scavenger. The CuTA nanozyme exhibits intrinsic superoxide dismutase-like activity, catalase-like activity, and hydroxyl radical elimination capacity. These synergistic antioxidant abilities make the CuTA nanozyme a promising candidate for the improvement of commercial cigarette filters. Mouse model results show that commercial cigarettes loaded with CuTA nanozyme efficiently scavenge ROS in the cigarette smoke, reduce oxidative stress-induced lung inflammation, and minimize the resultant acute lung injury. The developed CuTA nanozyme offers an efficient ROS scavenger with multiple antioxidant ability and opens up new opportunities for the modification of cigarette filters to reduce the toxic effects of cigarette smoke.
全球烟草流行仍然是对公众健康的毁灭性威胁。香烟烟雾中的有毒活性氧（ROS）无法被目前可用的香烟过滤嘴有效消除。由此产生的氧化应激会导致严重的肺损伤及进一步的疾病。为应对这一挑战，本文报道了一种新型的铜单宁酸配位（CuTA）纳米酶，它是一种高活性且热稳定的ROS清除剂。CuTA纳米酶具有内在的超氧化物歧化酶样活性、过氧化氢酶样活性和羟基自由基清除能力。这些协同的抗氧化能力使CuTA纳米酶成为改进商业香烟过滤嘴的有前途的候选者。小鼠模型结果表明，装载有CuTA纳米酶的商业香烟能有效清除香烟烟雾中的ROS，减轻氧化应激诱导的肺部炎症，并将由此导致的急性肺损伤降至最低。所开发的CuTA纳米酶提供了一种具有多种抗氧化能力的高效ROS清除剂，并为改良香烟过滤嘴以降低香烟烟雾的毒性作用开辟了新机会。
