Guo Weiyun, Wu Chaoyun, Li Guanghui, Wang Yonghui, He Shenghua, Huang Jihong, Gao Xueli, Yue Xiaoyue
Food and Pharmacy College, Xuchang University Xuchang 461000 China
College of Food and Bioengineering, Zhengzhou University of Light Industry Zhengzhou 450001 China.
RSC Adv. 2024 May 8;14(21):15106-15111. doi: 10.1039/d4ra00481g. eCollection 2024 May 2.
Glutathione (GSH) as an antioxidant greatly attenuates the reactive oxygen species (ROS) treatment strategy based on peroxidase-activity nanozymes. Therefore, nanozymes with multiple properties that generate ROS and further GSH-depletion functions would be of great benefit to improve antimicrobial efficacy. Herein, focusing on the green, safe and abundant functional prospects of metal-phenolic networks (MPNs) and the strong prospect of biomedical applications, we have synthesized copper tannic acid (CuTA) nanozymes with dual functional properties similar to peroxidase-like activity and GSH depletion. CuTA can catalyze the decomposition of HO to hydroxyl radicals (˙OH). In addition, CuTA nanozymes can efficiently deplete available GSH, thus enhancing ROS-mediated antimicrobial therapy. The antibacterial results show that CuTA has an excellent antibacterial effect against .
谷胱甘肽（GSH）作为一种抗氧化剂，极大地削弱了基于过氧化物酶活性纳米酶的活性氧（ROS）治疗策略。因此，具有产生ROS和进一步消耗GSH功能的多种特性的纳米酶将对提高抗菌效果大有裨益。在此，基于金属-酚网络（MPNs）绿色、安全且丰富的功能前景以及强大的生物医学应用前景，我们合成了具有类似于过氧化物酶样活性和GSH消耗双重功能特性的铜单宁酸（CuTA）纳米酶。CuTA可催化HO分解为羟基自由基（˙OH）。此外，CuTA纳米酶可有效消耗可用的GSH，从而增强ROS介导的抗菌治疗。抗菌结果表明，CuTA对……具有优异的抗菌效果。
