Chen Houminji, Miao Yuqing, Duan Haowen, Yi Shasha, Lin Zhengrong, Guo Yanwu, Zou Junjie, Niu Lili
Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, The National Key Clinic Specialty, The Engineering Technology Research Center of Education Ministry of China, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Front Neurosci. 2024 Nov 22;18:1499078. doi: 10.3389/fnins.2024.1499078. eCollection 2024.
Both physiotherapy and medicine play essential roles in the treatment of epilepsy. The purpose of this research was to evaluate the efficacy of the combined therapy with focus ultrasound stimulation (FUS) and gastrodin (GTD) on seizures in a mouse model. Kainic acid-induced seizure mice were divided into five groups randomly: sham, FUS, saline + sham, GTD + sham and GTD + FUS. The results showed that combined therapy with ultrasound stimulation and gastrodin can significantly reduce the number and duration of seizures in GTD + FUS group. 9.4T magnetic resonance imaging and histologic staining results revealed the underlying mechanism of the combined therapy may be that ultrasound stimulation increases cell membrane permeability to increase GTD concentration in brain. In addition, we verified the safety of FUS combined with GTD therapy. This research provides a new strategy for neurological disorders combining treatment of physical neuromodulation and medicine.
物理治疗和药物治疗在癫痫治疗中都起着至关重要的作用。本研究的目的是评估聚焦超声刺激（FUS）联合天麻素（GTD）治疗对小鼠癫痫模型发作的疗效。用 kainic 酸诱导癫痫发作的小鼠被随机分为五组：假手术组、FUS 组、生理盐水 + 假手术组、GTD + 假手术组和 GTD + FUS 组。结果表明，超声刺激联合天麻素治疗可显著减少 GTD + FUS 组的癫痫发作次数和持续时间。9.4T 磁共振成像和组织学染色结果显示，联合治疗的潜在机制可能是超声刺激增加细胞膜通透性，从而提高脑中 GTD 的浓度。此外，我们验证了 FUS 联合 GTD 治疗的安全性。本研究为结合物理神经调节和药物治疗的神经系统疾病提供了一种新策略。
