Yu Yue, Ye Juan, Wang Rubing, Wang JingJing, Wang Junnan, Xu Qiumeng, Wang Pei, Wang Bei, Zhang Yufeng
Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, People's Republic of China.
Department of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, People's Republic of China.
Ann Med Surg (Lond). 2024 Oct 28;86(12):7164-7177. doi: 10.1097/MS9.0000000000002681. eCollection 2024 Dec.
Cardiovascular diseases (CVDs) are the leading causes of death globally. The use of single-cell RNA sequencing (scRNA-seq) in CVDs has gained significant attention in recent years, and there is a growing body of literature on the subject. However, a thorough and impartial analysis of the existing state and trends of scRNA-seq in CVDs is lacking. This study aims to examine the development of scRNA-seq in CVDs using bibliometric and visualized analysis.
Global publications on scRNA-seq and CVDs from 2009 to 2023 were extracted from the Web of Science Core Collection (WoSCC) database. The R package "Bibliometrix", VOSviewer, and CiteSpace were employed to perform a bibliometric study.
After applying the screening criteria and omitting documents that met exclusive criteria, this bibliometric study included 1170 papers. These were authored by 8595 scholars from 1565 organizations in 57 countries or regions and were published in 369 journals, with 51 073 co-cited references included. Publication volume, citations, and relative research interest index focusing on this field have dramatically increased since 2019. The cooperation network showed that the USA, the Chinese Academy of Medical Sciences, and Qingbo Xu were the most active countries, institutes, and authors in this field, respectively. was the journal with the most publications, which was confirmed to be the top core source by Bradford's law. The hotspots and emerging direction in the field manifest in (1) three CVDs (atherosclerosis, myocardial infarction, and heart failure) and (2) three cell types (macrophage, fibroblast, and smooth muscle cell).
Our study provides a systematic visualization of the research literature on scRNA-seq in CVDs and provides guidance and reference for understanding the current research status and discovering new research directions.
心血管疾病（CVDs）是全球主要的死亡原因。近年来，单细胞RNA测序（scRNA-seq）在心血管疾病中的应用受到了广泛关注，相关文献也日益增多。然而，目前缺乏对心血管疾病中scRNA-seq现有状态和趋势的全面、公正分析。本研究旨在通过文献计量学和可视化分析来考察scRNA-seq在心血管疾病中的发展情况。
从Web of Science核心合集（WoSCC）数据库中提取2009年至2023年关于scRNA-seq和心血管疾病的全球出版物。使用R包“Bibliometrix”、VOSviewer和CiteSpace进行文献计量学研究。
在应用筛选标准并剔除符合排除标准的文献后，本项文献计量学研究纳入了1170篇论文。这些论文由来自57个国家或地区1565个机构的8595名学者撰写，发表在369种期刊上，共包含51073条共被引参考文献。自2019年以来，该领域的出版物数量、引用次数和相对研究兴趣指数均显著增加。合作网络显示，美国、中国医学科学院和徐清波分别是该领域最活跃的国家、机构和作者。 是发表论文最多的期刊，根据布拉德福定律被确认为顶级核心来源期刊。该领域的热点和新兴方向体现在（1）三种心血管疾病（动脉粥样硬化、心肌梗死和心力衰竭）和（2）三种细胞类型（巨噬细胞、成纤维细胞和平滑肌细胞）。
我们的研究为心血管疾病中scRNA-seq的研究文献提供了系统的可视化，并为理解当前研究现状和发现新的研究方向提供了指导和参考。
