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胸腺瘤合并霍奇金淋巴瘤:一例报告

Hodgkin lymphoma in pre-existing thymoma: a case report.

作者信息

AbuKhalaf Rahaf M, Zeer Zahraa M M, Abu Harb Zahra Hosam, Kamal Nazmi, Alseedat Yasmin, Sughayer Maher A

机构信息

Faculty of Medicine, Al-Quds University, Jerusalem, Palestine.

Department of Pathology, King Hussein Cancer Center, Amman, Jordan.

出版信息

Ann Med Surg (Lond). 2024 Oct 23;86(12):7390-7394. doi: 10.1097/MS9.0000000000002660. eCollection 2024 Dec.

DOI:10.1097/MS9.0000000000002660
PMID:39649895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11623889/
Abstract

INTRODUCTION

Thymus is a primary lymphoid organ which has an important role in humoral and cellular immunity. It can be a site for various neoplasms including thymomas.

CASE PRESENTATION

The authors report a case of a 55-year-old patient presenting with weight loss, night sweats and sensation of heat. After thorough evaluation his histopathology analysis revealed the rare presence of Hodgkin lymphoma in a background of type B2 thymoma.

DISCUSSION

Thymoma is one of the well-known thymic tumors that is encountered in clinical practice. It has diverse associations with other autoimmune diseases and malignancies. The concurrent diagnosis of thymoma with thymic Hodgkin lymphoma is extremely rare.

CONCLUSION

Although this association is very rare, it is crucial to distinguish between thymic Hodgkin lymphoma and thymoma and manage them appropriately.

摘要

引言

胸腺是一个主要的淋巴器官,在体液免疫和细胞免疫中发挥重要作用。它可能是包括胸腺瘤在内的各种肿瘤的发生部位。

病例介绍

作者报告了一例55岁患者,表现为体重减轻、盗汗和发热感。经过全面评估,其组织病理学分析显示在B2型胸腺瘤背景下罕见地存在霍奇金淋巴瘤。

讨论

胸腺瘤是临床实践中常见的胸腺肿瘤之一。它与其他自身免疫性疾病和恶性肿瘤有多种关联。胸腺瘤与胸腺霍奇金淋巴瘤的同时诊断极为罕见。

结论

尽管这种关联非常罕见,但区分胸腺霍奇金淋巴瘤和胸腺瘤并进行适当处理至关重要。

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本文引用的文献

1
Primary Thymic Hodgkin Lymphoma Coexisting with Thymoma and Myasthenia Gravis: A Case Report.原发性胸腺霍奇金淋巴瘤合并胸腺瘤和重症肌无力:一例报告。
Am J Case Rep. 2023 Nov 25;24:e941792. doi: 10.12659/AJCR.941792.
2
Thymoma: An Overview.胸腺瘤:概述
Diagnostics (Basel). 2023 Sep 18;13(18):2982. doi: 10.3390/diagnostics13182982.
3
The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines.SCARE 2023 指南:更新共识外科病例报告(SCARE)指南。
Int J Surg. 2023 May 1;109(5):1136-1140. doi: 10.1097/JS9.0000000000000373.
4
Incidence, mortality, and survival analyses of patients with thymic lymphoma.胸腺淋巴瘤患者的发病率、死亡率及生存分析。
Front Oncol. 2022 Sep 14;12:933672. doi: 10.3389/fonc.2022.933672. eCollection 2022.
5
An overview on the differential diagnostics of tumors of the anterior-superior mediastinum: the pathologist's perspective.前上纵隔肿瘤的鉴别诊断概述:病理学家的视角
Mediastinum. 2019 Feb 22;3:6. doi: 10.21037/med.2018.12.01. eCollection 2019.
6
T-Lymphoblastic Leukemia/Lymphoma and Thymoma: A Case Report and Review of the Literature of a Rare Association.T 淋巴细胞白血病/淋巴瘤和胸腺瘤:一种罕见关联的病例报告及文献复习。
Acta Haematol. 2022;145(1):106-111. doi: 10.1159/000519033. Epub 2021 Sep 17.
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Pitfalls of FNA diagnosis of thymic tumors.细针穿刺诊断胸腺瘤的陷阱。
Cancer Cytopathol. 2020 Jan;128(1):57-67. doi: 10.1002/cncy.22211. Epub 2019 Nov 19.
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T Cell/Histiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall.胸腺富于T细胞/组织细胞的大B细胞淋巴瘤:诊断陷阱
Case Rep Hematol. 2016;2016:2942594. doi: 10.1155/2016/2942594. Epub 2016 Jan 20.
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Epidemiology of thymoma and associated malignancies.胸腺瘤及相关恶性肿瘤的流行病学。
J Thorac Oncol. 2010 Oct;5(10 Suppl 4):S260-5. doi: 10.1097/JTO.0b013e3181f1f62d.
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Hodgkin disease of thymic origin.胸腺起源的霍奇金病。
J Thorac Cardiovasc Surg. 2002 Jun;123(6):1208-10. doi: 10.1067/mtc.2002.122113.