Macko M B, Powell C E
Ann Emerg Med. 1985 Jan;14(1):33-5. doi: 10.1016/s0196-0644(85)80732-0.
A double-blind randomized trial was performed to compare the subjective morbidity of tetanus toxoid (T) with that of tetanus-diphtheria toxoid (Td). Symptoms occurred in 46 (48%) of 93 patients who received T, and in 75 of 100 patients who received Td (chi 2 = 12.3; P less than .001). The effectiveness of immunization is clear, but with shift from use of T to Td as recommended, adherence to immunization guidelines and taking of adequate immunization histories becomes even more important.
进行了一项双盲随机试验，以比较破伤风类毒素（T）与破伤风 - 白喉类毒素（Td）的主观发病率。接受T的93例患者中有46例（48%）出现症状，接受Td的100例患者中有75例出现症状（卡方 = 12.3；P < 0.001）。免疫接种的有效性是明确的，但随着按照建议从使用T转向使用Td，遵守免疫接种指南并获取充分的免疫接种史变得更加重要。
