Murphy Jack F, Lavelle Martha, Asciak Lisa, Burdis Ross, Levis Hannah J, Ligorio Cosimo, McGuire Jamie, Polleres Marlene, Smith Poppy O, Tullie Lucinda, Uribe-Gomez Juan, Chen Biqiong, Dawson Jonathan I, Gautrot Julien E, Hooper Nigel M, Kelly Daniel J, Li Vivian S W, Mata Alvaro, Pandit Abhay, Phillips James B, Shu Wenmiao, Stevens Molly M, Williams Rachel L, Armstrong James P K, Huang Yan Yan Shery
Department of Engineering, University of Cambridge, Cambridge, CB2 1PZ UK.
Department of Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS1 3NY UK.
Biodes Manuf. 2024;7(6):825-856. doi: 10.1007/s42242-024-00316-z. Epub 2024 Oct 23.
As we navigate the transition from the Fourth to the Fifth Industrial Revolution, the emerging fields of biomanufacturing and biofabrication are transforming life sciences and healthcare. These sectors are benefiting from a synergy of synthetic and engineering biology, sustainable manufacturing, and integrated design principles. Advanced techniques such as 3D bioprinting, tissue engineering, directed assembly, and self-assembly are instrumental in creating biomimetic scaffolds, tissues, organoids, medical devices, and biohybrid systems. The field of biofabrication in the United Kingdom and Ireland is emerging as a pivotal force in bioscience and healthcare, propelled by cutting-edge research and development. Concentrating on the production of biologically functional products for use in drug delivery, in vitro models, and tissue engineering, research institutions across these regions are dedicated to innovating healthcare solutions that adhere to ethical standards while prioritising sustainability, affordability, and healthcare system benefits.
在我们从第四次工业革命向第五次工业革命过渡的过程中，生物制造和生物制造等新兴领域正在改变生命科学和医疗保健。这些领域正受益于合成生物学与工程生物学、可持续制造以及集成设计原则的协同作用。3D生物打印、组织工程、定向组装和自组装等先进技术有助于创建仿生支架、组织、类器官、医疗设备和生物杂交系统。在前沿研发的推动下，英国和爱尔兰的生物制造领域正在成为生物科学和医疗保健领域的一支关键力量。这些地区的研究机构专注于生产用于药物递送、体外模型和组织工程的生物功能产品，致力于创新符合道德标准的医疗保健解决方案，同时优先考虑可持续性、可负担性和医疗系统效益。
