Akber Malik Irfan, Iqbal Kashif, Bin Yamin Butt Jawad, Lodhi Muhammad Farhan, Muhammad Iqbal Saad, Iqbal Faisal, Khalid Mohammad Haroon, Khalil Hafiz Habib Ur Rehaman
Ophthalmology, Layton Rahmatullah Benevolent Trust (LRBT) Hospital Township, Lahore, PAK.
Ophthalmology, Akhtar Saeed Medical and Dental College, Lahore, PAK.
Cureus. 2024 Nov 7;16(11):e73250. doi: 10.7759/cureus.73250. eCollection 2024 Nov.
A wide variety of vitreoretinal diseases have been majorly treated by the use of pars plana vitrectomy (PPV) as the most commonly practiced treatment option. Despite the fact that it is the most feasible treatment modality, the probability of corneal endothelial cell damage following the treatment remains a matter of great concern. The study aims to inquire about the aftermath of PPV on endothelial cell density (ECD) and spans a time period of six months after the surgery has been performed.
This cross-sectional study involved 20 patients who underwent PPV at Layton Rahmatullah Benevolent Trust (LRBT) Hospital Township, Lahore, Pakistan. ECD was measured using non-contact specular microscopy preoperatively and at 15 days, two months, and six months postoperatively. The main outcome measured was the change in ECD over time, and the results were analyzed using descriptive statistics via SPSS software (version 25.0, IBM Corp., Armonk, NY).
The mean baseline ECD was 2,421 cells/mm², which decreased to 2,185 cells/mm² by the six-month follow-up, representing an overall mean ECD loss of 13.72%. Significant reductions in ECD were observed at each postoperative time point, with the most substantial decrease occurring within the first two months post-surgery.
Corneal endothelial cells are substantially influenced by PPV, which is significantly evident by the continuous reduction in ECD following surgery. The analysis calls attention to a careful and proper post-operative observation of corneal well-being is therefore required to alleviate likely endothelial damage along with the necessity of deliberate thinking while opting for the surgical techniques. The main focus of future studies should be on how to improve the current practices involving surgical procedures to ensure minimizing the loss of endothelial cells.
多种玻璃体视网膜疾病主要通过采用玻璃体切除术（PPV）作为最常用的治疗选择进行治疗。尽管它是最可行的治疗方式，但治疗后角膜内皮细胞受损的可能性仍然是一个备受关注的问题。该研究旨在探究玻璃体切除术对内皮细胞密度（ECD）的影响，并在手术后六个月的时间段内进行观察。
这项横断面研究纳入了20名在巴基斯坦拉合尔莱顿·拉赫马图拉慈善信托医院接受玻璃体切除术的患者。术前以及术后15天、两个月和六个月使用非接触式镜面显微镜测量内皮细胞密度。主要测量的结果是内皮细胞密度随时间的变化，并通过SPSS软件（版本25.0，IBM公司，纽约州阿蒙克）使用描述性统计分析结果。
平均基线内皮细胞密度为2421个细胞/mm²，到六个月随访时降至2185个细胞/mm²，内皮细胞密度总体平均损失为13.72%。在每个术后时间点均观察到内皮细胞密度显著降低，其中在手术后的头两个月内下降最为显著。
角膜内皮细胞受到玻璃体切除术的显著影响，手术后内皮细胞密度持续下降明显证明了这一点。该分析提醒需要对角膜健康进行仔细和适当的术后观察，以减轻可能的内皮损伤，同时在选择手术技术时需要慎重考虑。未来研究的主要重点应该是如何改进当前的手术操作方法，以确保最大限度地减少内皮细胞的损失。
