Duncan A M, Heddle J A, Blakey D H
Cancer Res. 1985 Jan;45(1):250-2.
The induction of karyorrhexis and "nuclear anomalies" in colonic crypt cells has been correlated positively with the induction of colonic tumors by chemical treatment. These nuclear anomalies occur in the proliferative region of the crypt and exhibit a variety of morphological characteristics. Some nuclear anomalies resemble the micronuclei that arise from chromosomal fragments after mitosis. Here, we report that the nuclear anomalies observed within the first few hr of insult with gamma-radiation are independent of mitosis for their expression, as evidenced by failure of colchicine to inhibit their induction, and do not arise from chromosomal material lost during mitosis.
结肠隐窝细胞中核碎裂和“核异常”的诱导与化学处理诱导结肠肿瘤呈正相关。这些核异常发生在隐窝的增殖区域，并表现出多种形态特征。一些核异常类似于有丝分裂后由染色体片段产生的微核。在此，我们报告，γ射线照射损伤后最初几小时内观察到的核异常，其表达不依赖于有丝分裂，秋水仙碱未能抑制其诱导可证明这一点，且并非由有丝分裂期间丢失的染色体物质产生。
