Li Meng, Song Meiying
Department of Gynecology, Fuxing Hospital, Capital Medical University, Beijing, China.
Front Public Health. 2024 Nov 22;12:1501409. doi: 10.3389/fpubh.2024.1501409. eCollection 2024.
Given the strong association between cardiovascular disease and human papillomavirus (HPV) infection, this study aimed to assess the correlation between HPV infection and cardiovascular health (CVH) as represented by the Life's Essential 8 (LE8) score.
This study employed analysis of data obtained from the National Health and Nutrition Examination Survey covering the period from 2005 to 2016. To examine the correlation between the CVH score and both HPV and high-risk HPV (HR-HPV) infections, this research utilized a combination of multivariable regression analysis, smooth curve fitting, and subgroup analysis, following adjustment for pertinent covariates.
This study included a total of 8,264 women, with an average age of 39.53 ± 11.24 years. The HPV prevalence was 43.43% overall, while the HR-HPV prevalence was 17.36%. In the fully adjusted model, an augmentation of 10 points in the CVH score correlated with an 8% reduction in the HPV infection rate [0.92 (0.88-0.96)], and a similar 8% decrease in the HR-HPV infection rate [0.92 (0.87-0.97)].
Our findings indicate that elevated CVH, as denoted by higher LE8 scores, correlates with a decreased of HPV infection rate among U.S. females. The LE8 score shows potential as a shared predictive biomarker for both CVH and HPV infection.
鉴于心血管疾病与人类乳头瘤病毒（HPV）感染之间存在密切关联，本研究旨在评估HPV感染与以生命八大要素（LE8）评分所代表的心血管健康（CVH）之间的相关性。
本研究采用了2005年至2016年期间美国国家健康与营养检查调查（National Health and Nutrition Examination Survey）的数据进行分析。为检验CVH评分与HPV及高危型HPV（HR-HPV）感染之间的相关性，本研究在对相关协变量进行调整后，采用了多变量回归分析、平滑曲线拟合及亚组分析相结合的方法。
本研究共纳入8264名女性，平均年龄为39.53±11.24岁。总体HPV感染率为43.43%，HR-HPV感染率为17.36%。在完全调整模型中，CVH评分每增加10分，HPV感染率降低8%[0.92（0.88-0.96）]，HR-HPV感染率也降低8%[0.92（0.87-0.97）]。
我们的研究结果表明，较高的LE8评分所代表的CVH水平升高与美国女性HPV感染率降低相关。LE8评分显示出作为CVH和HPV感染共同预测生物标志物的潜力。
