Cancer Center, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, China.
Department of Gastroenterology, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, China.
BMC Public Health. 2024 Oct 31;24(1):3028. doi: 10.1186/s12889-024-20546-1.
Human Papillomavirus (HPV) infection has garnered significant attention due to its high prevalence and association with various cancers and other health conditions. Composite lifestyle factors may influence the risk of HPV infection, yet their cumulative impact remains insufficiently explored. This study aims to explore the association between the Life's Essential 8 (LE8) Score and HPV infection status, highlighting the potential role of lifestyle and health behaviors in HPV infection prevention.
Utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005-2016, we analyzed the health and nutritional statuses of 6,773 participants after excluding those with missing HPV infection status, inability to calculate the LE8 Score, and missing covariate data. The LE8 Score was computed based on eight cardiovascular health metrics, encompassing both health factors (BMI, non-HDL cholesterol, blood pressure, and blood glucose) and health behaviors (physical activity, diet, sleep duration, and nicotine exposure). HPV infection status was determined through vaginal swab specimens analyzed using various Roche assays. Multivariate logistic regression, the restricted cubic splines (RCS) analysis and weighted quantile sum (WQS) regression were employed to assess the association between LE8 Score and HPV infection risk.
Our findings indicate a significant inverse association between the LE8 Score and HPV infection risk. Participants with medium and high LE8 Scores exhibited a 21% and 31% lower risk of HPV infection, respectively, compared to those with low LE8 Scores in multivariate logistic regression models. The analysis also revealed that lifestyle factors, particularly nicotine exposure and blood pressure, significantly contributed to the observed association.
The study underscores the importance of healthy lifestyle behaviors in reducing the risk of HPV infection. Public health strategies promoting such behaviors could complement existing HPV prevention measures, potentially lowering the burden of HPV-related diseases. Future research should further investigate the mechanisms underlying this association and the effectiveness of lifestyle interventions in diverse populations.
人乳头瘤病毒（HPV）感染因其高患病率以及与各种癌症和其他健康状况的关联而备受关注。综合生活方式因素可能会影响 HPV 感染的风险，但它们的累积影响仍未得到充分探索。本研究旨在探讨生命的八大要素（LE8）评分与 HPV 感染状况之间的关系，强调生活方式和健康行为在 HPV 感染预防中的潜在作用。
我们利用 2005-2016 年国家健康和营养检查调查（NHANES）的数据，在排除了 HPV 感染状况缺失、无法计算 LE8 评分以及缺失协变量数据的情况下，对 6773 名参与者的健康和营养状况进行了分析。LE8 评分是根据八项心血管健康指标计算得出的，包括健康因素（BMI、非高密度脂蛋白胆固醇、血压和血糖）和健康行为（身体活动、饮食、睡眠时长和尼古丁暴露）。HPV 感染状况通过阴道拭子标本进行检测，使用各种罗氏检测方法进行分析。我们采用多变量逻辑回归、限制三次样条（RCS）分析和加权分位数总和（WQS）回归来评估 LE8 评分与 HPV 感染风险之间的关系。
我们的研究结果表明，LE8 评分与 HPV 感染风险之间存在显著的负相关关系。在多变量逻辑回归模型中，与 LE8 评分较低的参与者相比，LE8 评分处于中、高水平的参与者 HPV 感染风险分别降低了 21%和 31%。分析还表明，生活方式因素，特别是尼古丁暴露和血压，对观察到的关联有显著贡献。
本研究强调了健康生活方式行为在降低 HPV 感染风险中的重要性。促进这种行为的公共卫生策略可以补充现有的 HPV 预防措施，可能降低 HPV 相关疾病的负担。未来的研究应进一步探讨这种关联的机制以及在不同人群中生活方式干预的效果。
