Gamba Guilherme, Colonetti Tamy, Uggioni Maria Laura Rodrigues, Elibio Laura Uggioni, Balbinot Eduarda Letícia, Heinzen Rebeca, Macedo Ana Cristina Lacerda, Grande Antonio José, da Rosa Maria Inês
Laboratory of Translational Biomedicine, Universidade do Extremo Sul Catarinense, Criciuma, SC, 88806-000, Brazil.
Universidade do Sul de Santa Catarina, Florianópolis, SC, Brazil.
Breast Cancer. 2025 Mar;32(2):242-257. doi: 10.1007/s12282-024-01658-3. Epub 2024 Dec 9.
The gastrointestinal microbiota can modulate systemic estrogens, potentially influencing estrogen-induced breast neoplasia development. This study aimed to assess alterations in the gut microbiota in breast cancer patients.
A search strategy was developed using the terms: "Microbiota," "Gastrointestinal Microbiome," "Breast Cancer," and synonyms. Ten observational studies were included.
The total sample was 1730 women (929 cases and 801 controls). The meta-analysis of alpha diversity, assessed by the Shannon index, displayed that in the breast cancer group, the diversity of the gut microbiota was reduced compared to controls, with a standardized mean difference (SMD) of - 0.34 (95% CI - 0.59, - 0.10, I = 68%, p = 0.007). Regarding the premenopausal population, there was a significant reduction in the breast cancer group (SMD - 0.67, 95% CI - 1.06, - 0.28, I = 77%, p = 0.0009). In women with a body mass index (BMI) between overweight or obesity, no statistically significant difference was observed (SMD - 0.20; 95% CI - 0.51, 0.11; I 52%, p = 0.20). However, in women with a BMI greater than or equal to 18.5 and less than 25.0, there was lower diversity in women with breast cancer compared to controls (SMD - 0.49, 95% CI - 0.94, - 0.04; I 78%, p = 0.03).
The study found a significant difference in gut microbiota diversity between women with breast cancer and controls, supporting the growing evidence that the gut microbiota may play a role in mammary carcinogenesis.
胃肠道微生物群可调节全身雌激素，可能影响雌激素诱导的乳腺肿瘤发生。本研究旨在评估乳腺癌患者肠道微生物群的变化。
使用术语“微生物群”“胃肠道微生物组”“乳腺癌”及其同义词制定检索策略。纳入了10项观察性研究。
总样本为1730名女性（929例病例和801例对照）。通过香农指数评估的α多样性的荟萃分析显示，与对照组相比，乳腺癌组肠道微生物群的多样性降低，标准化平均差（SMD）为-0.34（95%CI -0.59，-0.10，I=68%，p=0.007）。对于绝经前人群，乳腺癌组有显著降低（SMD -0.67，95%CI -1.06，-0.28，I=77%，p=0.0009）。在体重指数（BMI）处于超重或肥胖之间的女性中，未观察到统计学上的显著差异（SMD -0.20；95%CI -0.51，0.11；I 52%，p=0.20）。然而，在BMI大于或等于18.5且小于25.0的女性中，与对照组相比，乳腺癌女性的多样性较低（SMD -0.49，95%CI -0.94，-0.04；I 78%，p=0.03）。
该研究发现乳腺癌女性与对照组之间肠道微生物群多样性存在显著差异，支持了越来越多的证据表明肠道微生物群可能在乳腺癌发生中起作用。
