Shinomoto Makiko, Takeuchi Chisen, Tatebe Harutsugu, Kitani-Morii Fukiko, Ohmichi Takuma, Fujino Yuzo, Menjo Kanako, Terada Naoto, Osako Miho, Mochizuki Yoko, Teramukai Satoshi, Tokuda Takahiko, Mizuno Toshiki, Kasai Takashi
Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Department of Neurology, Tokyo Metropolitan Kita Medical and Rehabilitation Center for the Disabled, Tokyo, Japan.
PLoS One. 2024 Dec 9;19(12):e0311878. doi: 10.1371/journal.pone.0311878. eCollection 2024.
The Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID) is an appropriate screening tool for detecting dementia in Down's syndrome patients. However, whether this questionnaire reflects the neuropsychiatric signs of biomarker-confirmed Alzheimer's disease in DS (DS-AD) remains unknown. To address this issue, we compared the plasma phosphorylated tau (P181tau: p-tau) level of a representative AD biomarker with the total score and each sub-score of the DSQIID. The DSQIID was completed by 43 of the 56 individuals enrolled in the study. The DSQIID total scores tended to be positively associated with age, and some sub-scores increased in an age-dependent manner. DSQIID total scores and some sub-scores were also positively correlated with plasma p-tau levels, while all significant correlations disappeared after adjusting for age. Moreover, one sub-score appeared to have a significant negative correlation with plasma p-tau levels after adjusting for age. The DSQIID likely reflects age-associated behavioral changes in patients with DS. Meanwhile, their scores did not correlate with plasma p-tau after adjusting for age, suggesting that there might be room for improvement in the DSQIID for detecting DS-AD.
智力残疾者痴呆筛查问卷（DSQIID）是检测唐氏综合征患者痴呆的一种合适筛查工具。然而，该问卷是否能反映唐氏综合征合并阿尔茨海默病（DS-AD）中经生物标志物确认的阿尔茨海默病的神经精神症状仍不清楚。为解决这一问题，我们将一种具有代表性的AD生物标志物的血浆磷酸化tau蛋白（P181tau：p-tau）水平与DSQIID的总分及各子分数进行了比较。参与研究的56人中，有43人完成了DSQIID。DSQIID总分往往与年龄呈正相关，一些子分数随年龄增长而增加。DSQIID总分及一些子分数也与血浆p-tau水平呈正相关，但在调整年龄后，所有显著相关性均消失。此外，一个子分数在调整年龄后似乎与血浆p-tau水平呈显著负相关。DSQIID可能反映了唐氏综合征患者与年龄相关的行为变化。同时，在调整年龄后，他们的分数与血浆p-tau不相关，这表明DSQIID在检测DS-AD方面可能还有改进空间。
