Deb Shoumitro, Hare Monika, Prior Lindsay, Bhaumik Sabyasachi
Division of Neuroscience, Department of Psychiatry, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham, UK.
Br J Psychiatry. 2007 May;190:440-4. doi: 10.1192/bjp.bp.106.024984.
Many adults with Down's syndrome develop Alzheimer's dementia relatively early in their lives, but accurate clinical diagnosis remains difficult.
To develop a user-friendly observer-rated dementia screening questionnaire with strong psychometric properties for adults with intellectual disabilities.
We used qualitative methods to gather information from carers of people with Down's syndrome about the symptoms of dementia. This provided the items for the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID), which we then tested for its psychometric properties.
The DSQIID was administered to carers of 193 adults with Down's syndrome, 117 of whom were examined by clinicians who confirmed a diagnosis of dementia for 49 according to modified ICD-10 criteria. We established that a total score of 20 provides maximum sensitivity (0.92) and optimum specificity (0.97) for screening. The DSQIID has sound internal consistency (alpha=0.91) for all its 53 items, and good test-retest and interrater reliability. We established a good construct validity by dividing the items into four factors.
The DSQIID is a valid, reliable and user-friendly observer-rated questionnaire for screening for dementia among adults with Down's syndrome.
许多唐氏综合征成年人在相对年轻时就会患上阿尔茨海默病性痴呆，但准确的临床诊断仍然困难。
为智障成年人开发一种具有良好心理测量特性的、便于用户使用的由观察者评定的痴呆筛查问卷。
我们采用定性方法从唐氏综合征患者的照料者那里收集有关痴呆症状的信息。这为智障人士痴呆筛查问卷（DSQIID）提供了条目，然后我们对其心理测量特性进行了测试。
对193名唐氏综合征成年患者的照料者进行了DSQIID问卷调查，其中117人接受了临床医生的检查，临床医生根据修订的国际疾病分类第10版（ICD - 10）标准确诊49人患有痴呆。我们确定总分20分时筛查的灵敏度最高（0.92），特异性最佳（0.97）。DSQIID的全部53个条目具有良好的内部一致性（α = 0.91），重测信度和评分者间信度良好。通过将条目分为四个因子，我们建立了良好的结构效度。
DSQIID是一种有效、可靠且便于用户使用的由观察者评定的问卷，用于筛查唐氏综合征成年人中的痴呆。
