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填补空白:巴基斯坦人弥漫性脱发中的维生素D状况

Filling the Gaps: Vitamin D Status in Diffuse Hair Fall Among Pakistanis.

作者信息

Jalil Palwasha, Masood Sadia, Sadique Muhammad, Jalil Maimoona Abdul, Jalil Malghalura, Khan Laila

机构信息

Consultant Dermatologist at (Aria Institute of Medical Sciences Quetta).

Associate professor of Dermatology at Aga khan University Hospital Karachi.

出版信息

Dermatol Pract Concept. 2024 Oct 30;14(4):e2024232. doi: 10.5826/dpc.1404a232.

DOI:10.5826/dpc.1404a232
PMID:39652934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11620017/
Abstract

INTRODUCTION

Hair loss can happen for various reasons, including emotional stress, physical strain, certain medical issues, and nutritional gaps. When it comes to nutrition, a lack of vitamin D3 could be linked to diffuse hair loss.

OBJECTIVES

The aim was to look for the frequency of vitamin D3 deficiency with diffuse hair fall, especially in the Pakistani population.

METHODS

A total of 120 patients of both sexes and all ages presenting to the Dermatology Clinic with complaints of non-scarring alopecia and loss of over 100 strands of hair within a 24-hour period (counted by patient) of any duration and positive hair pull test were advised to take serum vitamin D3. Tests and results were then analyzed by SPSS statistical software package (version 19.0 for Windows).

RESULTS

The mean age of participants enrolled in the study was 28.56 ± 11.62 years. The majority of the patients, i.e., 77 (63.64%), were ≤30 years of age. Among the 120 patients, 17 were males and 103 were females. Mean serum vitamin D3 levels were 17.33 ± 5.43 ng/ml. 95 (79.17%) patients were found to be vitamin D3 deficient, with 37 patients having female pattern hair loss, seven patients with male pattern hair loss, seven patients with diffuse alopecia areata, and 44 patients with telogen effluvium.

CONCLUSIONS

This study concluded that there is considerable frequency of vitamin D3 deficiency in individuals with diffuse hair fall. Therefore, we recommend that there should be early recognition and treatment of this condition in these particular patients in order to reduce hair fall.

摘要

引言

脱发可能由多种原因引起,包括情绪压力、身体疲劳、某些医学问题和营养缺乏。在营养方面,维生素D3缺乏可能与弥漫性脱发有关。

目的

旨在寻找弥漫性脱发患者中维生素D3缺乏的发生率,尤其是在巴基斯坦人群中。

方法

共有120名来自皮肤科门诊的患者,不分性别和年龄,均有非瘢痕性脱发的主诉,且在任何时间段内24小时内脱发超过100根(由患者自行计数),且毛发牵拉试验呈阳性,建议他们检测血清维生素D3。然后使用SPSS统计软件包(Windows版19.0)对检测结果进行分析。

结果

参与该研究的患者平均年龄为28.56±11.62岁。大多数患者,即77名(63.64%)年龄≤30岁。120名患者中,男性17名,女性103名。血清维生素D3平均水平为17.33±5.43 ng/ml。95名(79.17%)患者被发现维生素D3缺乏,其中37名患者为女性型脱发,7名患者为男性型脱发,7名患者为弥漫性斑秃,44名患者为休止期脱发。

结论

本研究得出结论,弥漫性脱发患者中维生素D3缺乏的发生率相当高。因此,我们建议对这些特定患者应尽早识别和治疗这种情况,以减少脱发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ad6/11620017/8fc13dbb2745/dp1404a232g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ad6/11620017/8fc13dbb2745/dp1404a232g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ad6/11620017/8fc13dbb2745/dp1404a232g001.jpg

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本文引用的文献

1
Correlation of vitamin D and vitamin D receptor expression in patients with alopecia areata: a clinical paradigm.维生素 D 及其受体在斑秃患者中的表达相关性:一种临床范例。
Int J Dermatol. 2018 Feb;57(2):217-222. doi: 10.1111/ijd.13851. Epub 2017 Dec 15.
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The Role of Vitamin D in Non-Scarring Alopecia.维生素 D 在非瘢痕性脱发中的作用。
Int J Mol Sci. 2017 Dec 7;18(12):2653. doi: 10.3390/ijms18122653.
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Vitamin D Deficiency in Alopecia Areata.斑秃中的维生素D缺乏症
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Serum Vitamin D Levels and Diffuse Hair Fall among the Student Population in South India: A Case-Control Study.印度南部学生群体中血清维生素D水平与弥漫性脱发:一项病例对照研究。
Int J Trichology. 2016 Oct-Dec;8(4):160-164. doi: 10.4103/ijt.ijt_57_16.
5
Diet and hair loss: effects of nutrient deficiency and supplement use.饮食与脱发:营养缺乏及补充剂使用的影响
Dermatol Pract Concept. 2017 Jan 31;7(1):1-10. doi: 10.5826/dpc.0701a01. eCollection 2017 Jan.
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Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes.维生素D的生物活性形式可选择性刺激人类表皮角质形成细胞中下丘脑-垂体-肾上腺轴的皮肤类似物。
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A Guide to Studying Human Hair Follicle Cycling In Vivo.体内人毛囊周期研究指南
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Prevalence of Vitamin D deficiency in Pakistan and implications for the future.巴基斯坦维生素D缺乏症的患病率及其对未来的影响。
Expert Rev Clin Pharmacol. 2016;9(2):329-38. doi: 10.1586/17512433.2016.1122519. Epub 2016 Jan 13.
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The vitamin D receptor is required for activation of cWnt and hedgehog signaling in keratinocytes.维生素D受体是角质形成细胞中cWnt和刺猬信号通路激活所必需的。
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Evaluation and diagnosis of the hair loss patient: part I. History and clinical examination.脱发患者的评估和诊断:第一部分。病史和临床检查。
J Am Acad Dermatol. 2014 Sep;71(3):415.e1-415.e15. doi: 10.1016/j.jaad.2014.04.070.