Berman Jeffrey I, Bloy Luke, Ward Shana, Roberts Timothy P L
From the Program in Advanced Imaging Research and Department of Radiology (J.I.B., L.B., S.W., T.P.L.R.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Department of Radiology (J.I.B., T.P.L.R.), University of Pennsylvania, Philadelphia, Pennsylvania.
AJNR Am J Neuroradiol. 2025 Jun 3;46(6):1203-1207. doi: 10.3174/ajnr.A8618.
We propose a novel application of MR encephalography (MREG) to detect the frequency spectrum of endogenous slow oscillatory brain activity (delta, <4 Hz). MREG offers faster image acquisition than conventional fMRI and superior spatial localization than electroencephalography/magnetoencephalography. MREG was acquired at a 0.1-second temporal resolution in a healthy adult during interleaved wakefulness and sleep to demonstrate its capability for detecting delta-band power changes associated with sleep, previously demonstrated by electroencephalography. For each voxel, the brain activity of MREG signal was used to compute a spectrogram and a whole-brain image of delta-band spectral power. The delta-band power was observed to increase during sleep compared with the awake states using measures from MREG voxelwise spectrograms and sequential whole-brain spatial maps of slow-wave power. This work introduces an MR technique for measuring brain slow-wave activity that is sensitive to changes in the magnitude and frequency of brain activity in sleep.
我们提出了磁共振脑成像（MREG）的一种新应用，用于检测内源性慢振荡脑活动（δ波，<4Hz）的频谱。与传统功能磁共振成像相比，MREG能更快地采集图像，且与脑电图/脑磁图相比具有更好的空间定位。在一名健康成年人的清醒和睡眠交替期间，以0.1秒的时间分辨率采集MREG，以证明其检测与睡眠相关的δ波段功率变化的能力，这一能力先前已通过脑电图得到证实。对于每个体素，利用MREG信号的脑活动来计算频谱图和δ波段频谱功率的全脑图像。使用来自MREG体素级频谱图和慢波功率的连续全脑空间图的测量方法，观察到与清醒状态相比，睡眠期间δ波段功率增加。这项工作引入了一种用于测量脑慢波活动的磁共振技术，该技术对睡眠中脑活动的幅度和频率变化敏感。
