不同来源的抗菌肽：分离、纯化及其潜在应用的表征

Antimicrobial Peptides From Different Sources: Isolation, Purification, and Characterization to Potential Applications.

作者信息

Ahmed Shadi Ali Hassen, Saif Bassam, Qian Linghui

机构信息

College of Pharmaceutical Sciences, Hangzhou Institute of Innovative Medicine & Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang University, Hangzhou, China.

Key Laboratory of Applied Surface and Colloid Chemistry, School of Chemistry and Chemical Engineering, Ministry of Education, Shaanxi Normal University, Xi'an, China.

出版信息

J Sep Sci. 2024 Dec;47(23):e70043. doi: 10.1002/jssc.70043.

DOI:10.1002/jssc.70043

PMID:39654018

Abstract

Antimicrobial peptides (AMPs) are excellent promising candidates for biomedical applications owing to their structural properties, high biocompatibility, good biodegradability, and functional diversity. Unlike conventional antibiotics, AMPs have been shown to have broad-spectrum antimicrobial activity toward Gram-positive/negative bacteria, as well as antifungal and antiviral activity. These peptides have also been found to be cytotoxic to sperm and cancer cells. A range of AMPs has been isolated from various organisms, such as bacteria, fungi, plants, and animals. This review summarizes the latest studies on AMPs, covering their isolation, purification, and characterization as well as their potential biomedical applications and beyond.

摘要

抗菌肽（AMPs）因其结构特性、高生物相容性、良好的生物降解性和功能多样性，是生物医学应用中极具潜力的候选物。与传统抗生素不同，AMPs已被证明对革兰氏阳性/阴性细菌具有广谱抗菌活性，以及抗真菌和抗病毒活性。这些肽还被发现对精子和癌细胞具有细胞毒性。一系列AMPs已从各种生物体中分离出来，如细菌、真菌、植物和动物。本综述总结了关于AMPs的最新研究，涵盖其分离、纯化和表征，以及它们潜在的生物医学应用及其他方面。