Peng Shaoyi, Li Kaiyuan, Han Lingyu, Liu Peng
Department of Cardiology, The First People's Hospital of Jiande, Hangzhou, China.
Graduate School of Dalian Medical University, Dalian Medical University, Dalian, China.
Medicine (Baltimore). 2024 Dec 6;103(49):e40631. doi: 10.1097/MD.0000000000040631.
Cardiovascular diseases and dermatological conditions are prevalent health issues worldwide. Previous studies have suggested that risk factors for cardiovascular diseases may be associated with the development of dermatological conditions. However, the causal association between these factors remain unclear. This study utilized data from genome-wide association studies and applied Mendelian randomization (MR) to explore the potential causal association between cardiovascular risk factors and common dermatological conditions. Genetic variants significantly associated with low-density lipoprotein cholesterol (LDL-C), serum uric acid, blood glucose, and hypertension were selected as instrumental variables. We employed inverse variance weighted, MR Egger, and weighted mode methods for analysis. Sensitivity analyses, including Cochran Q test, MR-Egger intercept test, MR-PRESSO global test, and leave-one-out analysis, were conducted to ensure the robustness of the results. The MR analysis indicated a positive association between LDL-C levels and the risk of psoriasis (odds ratio [OR] = 1.23, 95% confidence interval [CI]: 1.03-1.47, P = .02). Additionally, hypertension and serum uric acid levels were positively associated with the risk of dermatitis eczema (hypertension: OR = 2.77, 95% CI: 1.23-6.24, P = .01; serum uric acid: OR = 1.09, 95% CI: 1.01-1.06, P = .01). This study provides evidence of a potential causal association between LDL-C levels and psoriasis, as well as between hypertension and serum uric acid levels and dermatitis eczema. These findings highlight the potential importance of cardiovascular health management in the prevention and treatment of common dermatological conditions. Further research is needed to validate these results and explore the underlying biological mechanisms.
心血管疾病和皮肤病是全球普遍存在的健康问题。先前的研究表明，心血管疾病的危险因素可能与皮肤病的发生有关。然而，这些因素之间的因果关系仍不清楚。本研究利用全基因组关联研究的数据，并应用孟德尔随机化（MR）方法来探索心血管危险因素与常见皮肤病之间的潜在因果关系。选择与低密度脂蛋白胆固醇（LDL-C）、血清尿酸、血糖和高血压显著相关的基因变异作为工具变量。我们采用逆方差加权法、MR-Egger法和加权中位数法进行分析。进行了敏感性分析，包括Cochran Q检验、MR-Egger截距检验、MR-PRESSO全局检验和留一法分析，以确保结果的稳健性。MR分析表明，LDL-C水平与银屑病风险呈正相关（优势比[OR]=1.23，95%置信区间[CI]：1.03-1.47，P=0.02）。此外，高血压和血清尿酸水平与皮炎湿疹风险呈正相关（高血压：OR=2.77，95%CI：1.23-6.24，P=0.01；血清尿酸：OR=1.09，95%CI：1.01-1.06，P=0.01）。本研究提供了LDL-C水平与银屑病之间以及高血压和血清尿酸水平与皮炎湿疹之间潜在因果关系的证据。这些发现突出了心血管健康管理在常见皮肤病预防和治疗中的潜在重要性。需要进一步的研究来验证这些结果并探索潜在的生物学机制。
