炎症与胆固醇：血管风险的十字路口
Inflammation and cholesterol at the crossroads of vascular risk.
机构信息
Division of Cardiac Surgery, Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute, St Michael's Hospital of Unity Health Toronto, Toronto, ON, Canada; Departments of Surgery, and Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
Department of Anesthesia, Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute, St Michael's Hospital of Unity Health Toronto, Toronto, ON, Canada; Departments of Anesthesiology and Pain Medicine, Physiology, and Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
出版信息
Cell Metab. 2023 Jul 11;35(7):1095-1098. doi: 10.1016/j.cmet.2023.06.011.
Although the role of inflammation in atherosclerosis is established, whether this relationship remains important after lowering low-density lipoprotein cholesterol (LDL-C) is still unclear. Recently in The Lancet, Ridker et al. demonstrated that residual inflammatory risk was a stronger predictor of fatal and non-fatal events compared to residual cholesterol risk, supporting the concept of inflammation testing to guide vascular risk reduction.
尽管炎症在动脉粥样硬化中的作用已得到确立，但在降低低密度脂蛋白胆固醇（LDL-C）后这种关系是否仍然重要尚不清楚。最近，里德克尔等人在《柳叶刀》杂志上表明，与残留胆固醇风险相比，残留炎症风险是致命和非致命事件的更强预测因子，这支持了通过炎症检测来指导血管风险降低的概念。
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