Erdem Miray, Soker Elif Banu, Ozdogru Derya, Balal Mehmet, Ciloglu Emine
Department of Neurology, Adana City Training and Research Hospital, Adana, Türkiye.
Department of Neurology, Çukurova University Faculty of Medicine, Adana, Türkiye.
Medicine (Baltimore). 2024 Dec 6;103(49):e40752. doi: 10.1097/MD.0000000000040752.
This study aimed to evaluate the presence and comparison of microvascular abnormalities in essential tremor (ET) and Parkinson disease (PD) using optical coherence tomography angiography (OCT-A) and to show the relationship between retinal microvascular changes and disease stage in the patient group. A total of 176 eyes, including 26 PD diagnosed according to the United Kingdom PD Society Brain Bank criteria, 31 ET diagnosed according to the Washington heights-inwood genetic study of ET (WHIGET) criteria and 31 healthy controls, were included in the study. Unified PD assessment scale (UPDRS) motor scores, non-motor symptom scale (NMS), modified Hoehn&Yahr stages (mH&Y) and Fahn-Toloso-Marin grading scale were recorded. All patients were evaluated in terms of visual acuity, fundus examination, intraocular pressure measurements, and refractive errors in Ophthalmology department. Deep macular vascular density was significantly decreased in PD compared to both the controls and ET(P < .05). In the measurements in the inferior quadrant of the retinal nerve fiber layer (RNFL) of the optic disc (OD), the values of the controls were significantly higher than those of PD in both eyes (P = .014 and P = .010). Radial peripapillary capillarity density in the left eye was substantially lower in ET than in controls (P = .045). In both eyes, OD radial peripapillary capillarity inside the disc small values of PD were significantly lower than those of ET and controls (P < .05). In our study, deep macular vascular density, RNFL and radial peripapillary capillarity were significantly lower in PD compared with ET and control groups, and radial peripapillary capillarity was lower in ET compared with control group. This study provides valuable information regarding the potential of OCT-A as a diagnostic tool for PD and ET.
本研究旨在利用光学相干断层扫描血管造影（OCT-A）评估特发性震颤（ET）和帕金森病（PD）中微血管异常的存在情况并进行比较，并展示患者组视网膜微血管变化与疾病分期之间的关系。该研究共纳入176只眼睛，其中包括根据英国帕金森病协会脑库标准诊断的26例帕金森病患者、根据华盛顿高地-因伍德特发性震颤基因研究（WHIGET）标准诊断的31例特发性震颤患者以及31名健康对照者。记录统一帕金森病评定量表（UPDRS）运动评分、非运动症状量表（NMS）、改良Hoehn&Yahr分期（mH&Y）和Fahn-Toloso-Marin分级量表。所有患者均在眼科进行了视力、眼底检查、眼压测量和屈光不正评估。与对照组和特发性震颤组相比，帕金森病患者的黄斑深层血管密度显著降低（P < 0.05）。在视盘（OD）视网膜神经纤维层（RNFL）下象限的测量中，对照组两眼的值均显著高于帕金森病患者（P = 0.014和P = 0.010）。特发性震颤患者左眼的视盘周围放射状毛细血管密度显著低于对照组（P = 0.045）。在两眼的视盘内，帕金森病患者视盘周围放射状毛细血管的小值均显著低于特发性震颤患者和对照组（P < 0.05）。在我们的研究中，与特发性震颤组和对照组相比，帕金森病患者的黄斑深层血管密度、RNFL和视盘周围放射状毛细血管密度显著降低，与对照组相比，特发性震颤患者的视盘周围放射状毛细血管密度降低。本研究提供了关于OCT-A作为帕金森病和特发性震颤诊断工具潜力的有价值信息。
