Castro Susana, Garcia-Aguilar Laura, Garcia-Brion Eduardo, Pérez-García Sofia, Rosique Consuelo, Baños Carmelo, Sanchez Irene
inGO Research Group, General Optica, Barcelona, Cataluña, Spain.
Departamento de Optometría y Visión, Universidad Complutense de Madrid, Madrid, Spain.
PeerJ. 2024 Dec 6;12:e18482. doi: 10.7717/peerj.18482. eCollection 2024.
The dropout rate of contact lens users has not decreased significantly over the years. Despite continuous improvements in contact lens (CL) designs, materials and surface treatments, the number of CL users who drop out remains similar to the number of new CL users. The aim of this study is to analyse the improvement in contact lens-associated dry eye disease (CLADE), quantified with the OSDI questionnaire when changing maintenance system solution from multipurpose solution to hydrogen peroxide.
This study included contact lens users for over a year as the multipurpose solution for the maintenance system, suffering from CLADE, and those who scored over 13 in the ocular surface disease index questionnaire, and did not manifest any clinical signs over 3 in the EFRON scale. The non-parametric data distribution was verified with the Kolmogorov-Smirnov test and Wilcoxon signed-rank test, which was used to compare the visual acuity (VA), OSDI score and bulbar redness (EFRON scale) of the follow-up visit against the baseline value.
Thirty-eight patients were included. Analysing the clinical parameters between the initial and final visit after one month of hydrogen peroxide use, a statistically significant improvement was found in the VA, bulbar hyperemia, OSDI scale and their subscales of the total sample ( < 0.04).
This study is intended as a first step towards a standardised protocol of actions to improve CLADE in an attempt to reduce contact lens dropout using OSDI as a tool for detection.
多年来，隐形眼镜佩戴者的辍学率并未显著下降。尽管隐形眼镜（CL）的设计、材料和表面处理不断改进，但退出使用隐形眼镜的用户数量仍与新用户数量相近。本研究的目的是分析当维护系统溶液从多功能溶液改为过氧化氢时，用眼表疾病指数（OSDI）问卷量化的隐形眼镜相关性干眼疾病（CLADE）的改善情况。
本研究纳入了使用多功能溶液作为维护系统超过一年、患有CLADE且眼表疾病指数问卷得分超过13分、在埃弗龙量表上无任何超过3分临床体征的隐形眼镜佩戴者。通过柯尔莫哥洛夫-斯米尔诺夫检验和威尔科克森符号秩检验验证非参数数据分布，这些检验用于比较随访时的视力（VA）、OSDI评分和球结膜充血（埃弗龙量表）与基线值。
纳入38例患者。分析使用过氧化氢一个月后初次和末次就诊之间的临床参数，发现总样本的VA、球结膜充血、OSDI量表及其子量表有统计学显著改善（<0.04）。
本研究旨在作为朝着改善CLADE的标准化行动方案迈出的第一步，试图以OSDI作为检测工具来减少隐形眼镜停用情况。
