Bardakci Mustafa Ilteris, Ayhan Albayrak Gulhan
Department of Chest Diseases, Sisli Hamidiye Etfal Training and Research Hospital.
Sarcoidosis Vasc Diffuse Lung Dis. 2024 Dec 10;41(4):e2024049. doi: 10.36141/svdld.v41i4.15760.
Sarcoidosis can affect every organ with varying frequency based on ethnicity, gender and age. We aimed to evaluate the health-related quality of life (HRQoL) and fatigue levels of our sarcoidosis patients. However, our second aim is to determine whether patient or disease markers correlate with quality of life assessment questionnaires.
Pulmonary sarcoidosis patients who were followed up in the chest diseases outpatient clinic of our hospital were included in this prospective study. In the follow-up of 2023, routine blood tests, angiotensin-converting enzyme (ACE), posteroanterior lung (thorax computed tomography in patients with parenchymal involvement) were requested from the patients. Participants were asked to fill out the short-form 36-item questionnaire (SF-36), fatigue assessment scale (FAS) and fatigue severity scale (FSS) under the control of the outpatient clinic.
A total of 189 patients, 139 (73.5%) female and 50 (26.5%) male, diagnosed with Sarcoidosis were included. The mean age of our patients was 53.1±13.6. ACE (IU/L) 68.5±44.5. Of the patients we followed up for pulmonary sarcoidosis, 111 (58.7%) had single organ involvement and 78 (41.3%) had additional organ involvement. FAS; It was high in 103 (64.3%) patients and 29 (15.3%) were very tired. FSS value was 4.45±0.7 (3-5.88). All SF-36 parameters were lower than expected; MH and SF was minimally lower, PF, RP, BP, GH, RE and VT were significantly lower. SF-36 scores were found to be lower in the women and additional organ involvement participating.
We found a significant decrease in HRQoL and an increase in fatigue scores of our patients. These changes were more pronounced in women participating in the study than in men. In addition, the involvement of additional organs with the lung negatively affected the quality of life.
结节病可累及各个器官，其发生频率因种族、性别和年龄而异。我们旨在评估结节病患者的健康相关生活质量（HRQoL）和疲劳水平。然而，我们的第二个目的是确定患者或疾病标志物是否与生活质量评估问卷相关。
本前瞻性研究纳入了在我院胸科门诊随访的肺结节病患者。在2023年的随访中，要求患者进行常规血液检查、血管紧张素转换酶（ACE）检测、后前位胸部X线检查（实质受累患者进行胸部计算机断层扫描）。参与者在门诊的指导下填写36项简短问卷（SF-36）、疲劳评估量表（FAS）和疲劳严重程度量表（FSS）。
共纳入189例诊断为结节病的患者，其中女性139例（73.5%），男性50例（26.5%）。患者的平均年龄为53.1±13.6岁。ACE（IU/L）为68.5±44.5。在我们随访的肺结节病患者中，111例（58.7%）为单器官受累，78例（41.3%）有其他器官受累。FAS：103例（64.3%）患者得分较高，29例（15.3%）非常疲劳。FSS值为4.45±0.7（3 - 5.88）。所有SF-36参数均低于预期；MH和SF略低，PF、RP、BP、GH、RE和VT显著降低。发现参与研究的女性和有其他器官受累者的SF-36评分较低。
我们发现患者的HRQoL显著下降，疲劳评分增加。这些变化在参与研究的女性中比男性更明显。此外，肺部以外的其他器官受累对生活质量产生负面影响。
