Koeppel Maximilian, Steindorf Karen, Schmidt Martina E, Rosenberger Friederike, Wiskemann Joachim
Institute of Sports and Sport Science, Heidelberg University, Heidelberg, Germany.
Working Group Exercise Oncology, Department of Medical Oncology, National Center for Tumor Diseases Heidelberg (NCT Heidelberg) and Heidelberg University Hospital, a partnership between DKFZ and University Medical Center Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany.
Support Care Cancer. 2024 Dec 10;33(1):12. doi: 10.1007/s00520-024-09001-4.
In resistance training (RT), the change in volume-load from training sessions (TS) to TS is an indicator of training progress. Resulting growth trajectories are likely to differ between individuals. Understanding this variation is important for exercise planning in general, but even more for clinical populations. We investigated this variation in breast cancer patients undergoing treatment.
Data of 69 patients from two randomized controlled trails were investigated. They conducted a 12-week RT program. We fitted a quadratic Bayesian regression model to the baseline standardized volume-load over the course of the intervention. We allowed all parameters to vary both between exercises and between individuals.
We observed a positive linear component of 0.093 (95% uncertainty interval (UI) 0.058 to 0.120) and a negative quadratic component of - 0.002 (95% UI -0.008 to 0.001) for the mean trajectory of the change in volume-load. For the different exercises, we observed a dispersion for both the linear (0.043, 95% UI 0.018 to 0.082) and the quadratic component (0.002, 95% UI < 0.001 to 0.004). Variation between individual appears to be approximately four times larger. We also observed between-exercise variation within individuals. Extrapolation of the regression model indicates training progression stagnates after 20.6 TS (95% UI 14.8 to 44.4).
There is substantial variation in RT response between breast cancer patients undergoing tumor therapy and in-between exercises. The non-linear trajectory indicates that training progression will eventually plateau, demanding periodization and timely modification.
BEATE Study: NCT01106820, Date: April 20, 2010; BEST Study: NCT01468766, Date: November 9, 2011.
在抗阻训练（RT）中，从训练课（TS）到TS的容量负荷变化是训练进展的一个指标。个体之间的生长轨迹可能存在差异。总体而言，了解这种差异对运动计划很重要，对于临床人群而言更是如此。我们调查了接受治疗的乳腺癌患者的这种差异。
对来自两项随机对照试验的69例患者的数据进行了调查。他们进行了为期12周的RT计划。我们对干预过程中基线标准化容量负荷拟合了二次贝叶斯回归模型。我们允许所有参数在不同练习之间以及个体之间变化。
对于容量负荷变化的平均轨迹，我们观察到正线性成分0.093（95%不确定区间（UI）0.058至0.120）和负二次成分-0.002（95%UI -0.008至0.001）。对于不同的练习，我们观察到线性成分（0.043，95%UI 0.018至0.082）和二次成分（0.002，95%UI<0.001至0.004）均存在离散度。个体之间的差异似乎大约大4倍。我们还观察到个体内部不同练习之间的差异。回归模型的外推表明，在20.6次TS（95%UI 14.8至44.4）后训练进展停滞。
接受肿瘤治疗的乳腺癌患者之间以及不同练习之间的RT反应存在显著差异。非线性轨迹表明训练进展最终将趋于平稳，需要进行周期化和及时调整。
BEATE研究：NCT01106820，日期：2010年4月20日；BEST研究：NCT01468766，日期：2011年11月9日。
