力量训练对癌症患者和幸存者的肌肉肥大作用：一项荟萃分析和荟萃回归研究。
Muscle hypertrophy in cancer patients and survivors via strength training. A meta-analysis and meta-regression.
机构信息
Institute of Sports and Sport Science, Heidelberg University, Im Neuenheimer Feld 700, 69120, Heidelberg, Germany; Working Group Exercise Oncology, Division of Medical Oncology, National Center for Tumor Diseases Heidelberg (NCT Heidelberg) and Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany; Penn State College of Medicine, University Drive 500, 17033, Hershey, PA, USA.
Penn State College of Medicine, University Drive 500, 17033, Hershey, PA, USA; Harrisburg Area Community College, Bldg. YL150, 17401, YORK, PA, USA.
出版信息
Crit Rev Oncol Hematol. 2021 Jul;163:103371. doi: 10.1016/j.critrevonc.2021.103371. Epub 2021 May 29.
BACKGROUND
Muscle wasting has a negative effect on treatment toxicity and cancer prognosis. Resistance training appears to be a promising approach to counteract the loss of muscle mass.
METHODS
Pubmed, Cochrane Library, SportDiscus and CINAHL. Randomized controlled resistance training trials with cancer survivros where eligible if lean body mass (LBM) or muscle mass were assessed.
RESULTS
A total of 34 trials were included into the primary analysis. Compared to the control individuals, the intervention groups show a superiority in LBM of 0.85 kg (95 % CI = 0.26-1.43, p = .004). Isolated, the participants in the intervention groups show an increase in LBM of 0.51 kg (95 % CI = -0.05-1.06, p = .072); the control groups displayed a decrease of -0.59 kg (95 % CI= -1.04 to 0.06, p = .078). Supervision displayed an mediating role.
CONCLUSIONS
Resistance training can counteract the loss of muscle mass in cancer patients. Especially in a supervised setting.
背景
肌肉减少对治疗毒性和癌症预后有负面影响。抗阻训练似乎是一种对抗肌肉质量损失的有前途的方法。
方法
使用 Pubmed、Cochrane Library、SportDiscus 和 CINAHL 进行检索。纳入有肌肉质量或去脂体重（lean body mass，LBM）评估的癌症幸存者的随机对照抗阻训练试验。
结果
共有 34 项试验纳入主要分析。与对照组相比，干预组的 LBM 优势为 0.85 公斤（95%置信区间为 0.26-1.43，p=0.004）。单独来看，干预组的参与者的 LBM 增加了 0.51 公斤（95%置信区间为-0.05-1.06，p=0.072）；对照组的 LBM 减少了 0.59 公斤（95%置信区间为-1.04 至 0.06，p=0.078）。监督显示出中介作用。
结论
抗阻训练可以对抗癌症患者的肌肉减少。特别是在监督的环境下。
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