Kathiresan Nachammai, Selvaraj Chandrabose, Subbaraj Gowtham Kumar, Langeswaran Kulanthaivel
Department of Biotechnology, Alagappa University, Science Campus, Karaikudi, Tamil Nadu, India.
CsrDD Lab, Department of Microbiology, Dr. D. Y. Patil Medical College Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pimpri, Pune, 411018, India.
Neurol Sci. 2025 Apr;46(4):1925-1927. doi: 10.1007/s10072-024-07925-7. Epub 2024 Dec 10.
Alzheimer's Disease (AD), a neurodegenerative disorder characterized by cognitive decline, has traditionally relied on pharmacological interventions. However, the limitations of current treatments have spurred interest in neurosurgical approaches. This review explores the potential of neurosurgery, particularly deep brain stimulation (DBS), in modifying disease progression and enhancing cognitive function in AD patients. While promising, significant challenges, including surgical precision, patient variability, and ethical considerations, hinder widespread application. The future of neurosurgical interventions lies in minimally invasive techniques, novel neurostimulation methods, and precision neurosurgery guided by advanced imaging and neurophysiological mapping. As research advances, neurosurgery may emerge as a valuable tool in the comprehensive management of AD.
阿尔茨海默病（AD）是一种以认知功能衰退为特征的神经退行性疾病，传统上依赖药物干预。然而，当前治疗方法的局限性激发了人们对神经外科手术方法的兴趣。本综述探讨了神经外科手术，特别是深部脑刺激（DBS），在改变AD患者疾病进展和增强认知功能方面的潜力。尽管前景广阔，但包括手术精度、患者个体差异和伦理考量在内的重大挑战阻碍了其广泛应用。神经外科手术干预的未来在于微创技术、新型神经刺激方法以及由先进成像和神经生理图谱引导的精准神经外科手术。随着研究的进展，神经外科手术可能会成为AD综合管理中的一种有价值的工具。
