Sharifzadeh Afsheen, Wetstone Rachel, Chen Li-Chi, Guilarte-Walker Yurima, Flahive Julie, Harris John E
Department of Dermatology, UMass Chan Medical School, Worcester, MA, USA.
Florida International University, Herbert Wertheim College of Medicine, Miami, FL, USA.
Br J Dermatol. 2025 Mar 18;192(4):753-755. doi: 10.1093/bjd/ljae478.
Our study demonstrated that adults with vitiligo had a 1.5-unit lower BMI [mean (SD) 27.8 (6.1) vs. 29.3 (7.2) kg m; = 0.001], but higher risk of hyperlipidaemia [aOR 1.40, 95% CI (1.12–1.70)] and hypercholesterolaemia [aOR 1.44, 95% CI (1.10–1.90)] compared with age-, sex- and race-matched subjects without vitiligo. The inverse association between BMI and vitiligo was independent of the presence of concomitant cardiometabolic diseases. Additionally, we contextualized these findings in relation to other immune-mediated skin disorders, including alopecia areata and psoriasis, to explore underlying pathogenesis and guide the development of appropriate screening criteria.
我们的研究表明，患有白癜风的成年人体重指数（BMI）低1.5个单位[平均值（标准差）为27.8（6.1）vs. 29.3（7.2）kg/m²；P = 0.001]，但与年龄、性别和种族匹配的无白癜风受试者相比，高脂血症风险更高[调整后比值比（aOR）为1.40，95%置信区间（CI）为（1.12 - 1.70）]，高胆固醇血症风险更高[aOR为1.44，95%CI为（1.10 - 1.90）]。BMI与白癜风之间的负相关独立于合并的心脏代谢疾病。此外，我们将这些发现与其他免疫介导的皮肤病，包括斑秃和银屑病进行关联，以探索潜在的发病机制并指导制定合适的筛查标准。
