时空转录组和单细胞RNA测序分析表明，IKFZ1介导的小胶质细胞是脑出血治疗的基础。 - Suppr

Spatiotemporal transcriptome and scRNA sequencing analysis reveals that IKFZ1-mediated microglia underlies a therapy for intracerebral hemorrhage.

作者信息

Qiu Wenqiao, Tian Jie, Mou Gao, Guo Lili, Xu Tao, Liu Wei, Zhu Jianwei, Zhang Yi, Hou Xiaolin, Xie Yao, Xiong Huan, Li Xinda, Wang Yangyang, Gao Mingjun, Wu Anguo, Chen Longyi, Mei Jie, Huang Lulin, Xu Ruxiang

机构信息

Department of Neurosurgery, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.

出版信息

Clin Transl Med. 2024 Dec;14(12):e70127. doi: 10.1002/ctm2.70127.

DOI:10.1002/ctm2.70127

PMID:39658532

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11631562/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4be2/11631562/20ab28cb01ed/CTM2-14-e70127-g002.jpg

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本文引用的文献

Pyroptosis Signature Gene CHMP4B Regulates Microglia Pyroptosis by Inhibiting GSDMD in Alzheimer's Disease.

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The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in diabetic retinopathy.

Front Immunol. 2023 Apr 25;14:1151185. doi: 10.3389/fimmu.2023.1151185. eCollection 2023.

Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis.

Transl Neurodegener. 2023 Mar 9;12(1):10. doi: 10.1186/s40035-023-00343-3.

Mesenchymal stem cell-derived extracellular vesicles/exosome: A promising therapeutic strategy for intracerebral hemorrhage.

Regen Ther. 2023 Feb 18;22:181-190. doi: 10.1016/j.reth.2023.01.006. eCollection 2023 Mar.

Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration.

Brain Behav Immun. 2023 Mar;109:144-161. doi: 10.1016/j.bbi.2023.01.016. Epub 2023 Jan 23.

Application of stem cells and exosomes in the treatment of intracerebral hemorrhage: an update.

Stem Cell Res Ther. 2022 Jun 28;13(1):281. doi: 10.1186/s13287-022-02965-2.

Cell pyroptosis in health and inflammatory diseases.

Cell Death Discov. 2022 Apr 11;8(1):191. doi: 10.1038/s41420-022-00998-3.

The Changes of Leukocytes in Brain and Blood After Intracerebral Hemorrhage.

Front Immunol. 2021 Feb 15;12:617163. doi: 10.3389/fimmu.2021.617163. eCollection 2021.

TREM-1 Exacerbates Neuroinflammatory Injury via NLRP3 Inflammasome-Mediated Pyroptosis in Experimental Subarachnoid Hemorrhage.

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Spatiotemporal transcriptome and scRNA sequencing analysis reveals that IKFZ1-mediated microglia underlies a therapy for intracerebral hemorrhage.

作者信息

机构信息

Department of Neurosurgery, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.

出版信息

Clin Transl Med. 2024 Dec;14(12):e70127. doi: 10.1002/ctm2.70127.

DOI:10.1002/ctm2.70127

PMID:39658532

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11631562/

Abstract

摘要

相似文献

Spatiotemporal transcriptome and scRNA sequencing analysis reveals that IKFZ1-mediated microglia underlies a therapy for intracerebral hemorrhage.

Clin Transl Med. 2024 Dec;14(12):e70127. doi: 10.1002/ctm2.70127.

ATAT1 deficiency enhances microglia/macrophage-mediated erythrophagocytosis and hematoma absorption following intracerebral hemorrhage.

Neural Regen Res. 2024 May;19(5):1072-1077. doi: 10.4103/1673-5374.382984.

Single-cell RNA sequencing reveals the evolution of the immune landscape during perihematomal edema progression after intracerebral hemorrhage.

J Neuroinflammation. 2024 May 28;21(1):140. doi: 10.1186/s12974-024-03113-8.

Fifty Shades of Microglia.

Trends Neurosci. 2019 Jul;42(7):440-443. doi: 10.1016/j.tins.2019.03.010. Epub 2019 Apr 18.

Transcriptomic profiling of retinal cells reveals a subpopulation of microglia/macrophages expressing Rbpms marker of retinal ganglion cells (RGCs) that confound identification of RGCs.

Brain Res. 2023 Jul 15;1811:148377. doi: 10.1016/j.brainres.2023.148377. Epub 2023 Apr 28.

Spi1 regulates the microglial/macrophage inflammatory response via the PI3K/AKT/mTOR signaling pathway after intracerebral hemorrhage.

Neural Regen Res. 2024 Jan;19(1):161-170. doi: 10.4103/1673-5374.375343.

Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage.

J Cereb Blood Flow Metab. 2017 Jul;37(7):2383-2395. doi: 10.1177/0271678X16666551. Epub 2016 Jan 1.

J Neuroinflammation. 2017 Feb 14;14(1):36. doi: 10.1186/s12974-017-0790-0.

Single-cell and Spatial Transcriptomics Reveals Ferroptosis as The Most Enriched Programmed Cell Death Process in Hemorrhage Stroke-induced Oligodendrocyte-mediated White Matter Injury.

Int J Biol Sci. 2024 Jul 8;20(10):3842-3862. doi: 10.7150/ijbs.96262. eCollection 2024.

The dual role of microglia in intracerebral hemorrhage.

Behav Brain Res. 2024 Sep 13;473:115198. doi: 10.1016/j.bbr.2024.115198. Epub 2024 Aug 10.

本文引用的文献

Pyroptosis Signature Gene CHMP4B Regulates Microglia Pyroptosis by Inhibiting GSDMD in Alzheimer's Disease.

Mol Neurobiol. 2025 Jan;62(1):77-90. doi: 10.1007/s12035-024-04255-9. Epub 2024 Jun 1.

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in diabetic retinopathy.

Front Immunol. 2023 Apr 25;14:1151185. doi: 10.3389/fimmu.2023.1151185. eCollection 2023.

Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis.

Transl Neurodegener. 2023 Mar 9;12(1):10. doi: 10.1186/s40035-023-00343-3.

Mesenchymal stem cell-derived extracellular vesicles/exosome: A promising therapeutic strategy for intracerebral hemorrhage.

Regen Ther. 2023 Feb 18;22:181-190. doi: 10.1016/j.reth.2023.01.006. eCollection 2023 Mar.

Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration.

Brain Behav Immun. 2023 Mar;109:144-161. doi: 10.1016/j.bbi.2023.01.016. Epub 2023 Jan 23.

Application of stem cells and exosomes in the treatment of intracerebral hemorrhage: an update.

Stem Cell Res Ther. 2022 Jun 28;13(1):281. doi: 10.1186/s13287-022-02965-2.

Cell pyroptosis in health and inflammatory diseases.

Cell Death Discov. 2022 Apr 11;8(1):191. doi: 10.1038/s41420-022-00998-3.

The Changes of Leukocytes in Brain and Blood After Intracerebral Hemorrhage.

Front Immunol. 2021 Feb 15;12:617163. doi: 10.3389/fimmu.2021.617163. eCollection 2021.

TREM-1 Exacerbates Neuroinflammatory Injury via NLRP3 Inflammasome-Mediated Pyroptosis in Experimental Subarachnoid Hemorrhage.

Transl Stroke Res. 2021 Aug;12(4):643-659. doi: 10.1007/s12975-020-00840-x. Epub 2020 Aug 30.

Spatiotemporal transcriptome and scRNA sequencing analysis reveals that IKFZ1-mediated microglia underlies a therapy for intracerebral hemorrhage.

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Spatiotemporal transcriptome and scRNA sequencing analysis reveals that IKFZ1-mediated microglia underlies a therapy for intracerebral hemorrhage.

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