Schauder P, Herbertz L, Langenbeck U
Metabolism. 1985 Jan;34(1):58-61. doi: 10.1016/0026-0495(85)90061-7.
Eight healthy individuals were fasted for 72 hours. The concentrations of the branched chain keto acids (BCKA), branched chain amino acids (BCAA), C peptide, and glucagon were determined in peripheral venous blood. alpha-ketoisocaproic acid, alpha-keto-beta-methyl-n-valeric acid, and alpha-ketoisovaleric acid increased significantly within 36 hours along with the corresponding amino acids. After 60 hours of starvation, the concentrations of BCKA and BCAA declined despite the fact that the subjects were still in the fasting state. These changes were accompanied by a decrease in the concentrations of C peptide and an increase in glucagon levels. It is suggested that in starving man insulinopenia may contribute to the rise in BCKA concentrations and that the increase in BCKA may be a mechanism to reduce proteolysis.
八名健康个体禁食72小时。测定外周静脉血中支链酮酸（BCKA）、支链氨基酸（BCAA）、C肽和胰高血糖素的浓度。α-酮异己酸、α-酮-β-甲基-n-戊酸和α-酮异戊酸在36小时内与相应氨基酸一同显著增加。饥饿60小时后，尽管受试者仍处于禁食状态，但BCKA和BCAA的浓度下降。这些变化伴随着C肽浓度的降低和胰高血糖素水平的升高。提示在饥饿的人体中，胰岛素缺乏可能导致BCKA浓度升高，且BCKA的增加可能是减少蛋白水解的一种机制。
