Radwan Roqaia E, El-Kholy Wafaa M, Elsaed Afaf, Darwish Ahmad
Physiology Section, Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
Genetics Unit, Children Hospital, Mansoura University, Mansoura, Egypt.
BMC Cancer. 2024 Dec 10;24(1):1509. doi: 10.1186/s12885-024-13224-3.
Evading apoptosis fuels the aggressive nature of acute lymphoblastic leukemia (ALL). This study explored the potential roles of TNF-α, a pro-apoptotic cytokine, and TGF-β, a pro-proliferative factor, in the risk of developing ALL in Egyptian children. We investigated the TNF-α rs1800629 polymorphism and serum TGF-β levels in 100 ALL patients and 100 healthy controls. Notably, specific variations in TNF-α (GA, AA genotypes, and dominant model) were associated with an increased risk of ALL, suggesting impaired apoptosis. Conversely, ALL patients exhibited significantly lower TGF-β levels, potentially promoting uncontrolled proliferation. Our findings suggest that lower TGF-β and the TNF-α (-308) dominant model are associated with an increased risk of ALL. Additionally, TGF-β demonstrated exceptional accuracy (AUC 0.995) as a potential marker, with 100% sensitivity and 96% specificity. These findings suggest that TNF-α and TGF-β may be associated with ALL susceptibility, though further research with larger and more diverse populations is necessary to confirm these results.
逃避细胞凋亡助长了急性淋巴细胞白血病（ALL）的侵袭性。本研究探讨了促凋亡细胞因子TNF-α和促增殖因子TGF-β在埃及儿童患ALL风险中的潜在作用。我们调查了100例ALL患者和100名健康对照者的TNF-α rs1800629多态性和血清TGF-β水平。值得注意的是，TNF-α的特定变异（GA、AA基因型和显性模型）与ALL风险增加相关，提示细胞凋亡受损。相反，ALL患者的TGF-β水平显著降低，可能促进了不受控制的增殖。我们的研究结果表明，较低的TGF-β水平和TNF-α（-308）显性模型与ALL风险增加相关。此外，TGF-β作为一种潜在标志物表现出极高的准确性（AUC为0.995），敏感性为100%，特异性为96%。这些研究结果表明，TNF-α和TGF-β可能与ALL易感性相关，不过需要对更大且更多样化的人群进行进一步研究以证实这些结果。
