Mushtaq Sana, Hassan Muhammad Arslan Ul, Li Yan, Abdi Ikran, Ahmad Aqsa, Li HaiNing
Department of Gynecology, General Hospital of Ningxia Medical University, Yinchuan 750004, China.
The First Clinical Medical College of Ningxia Medical University, Yinchuan 750004, China.
Case Rep Womens Health. 2024 Nov 26;44:e00670. doi: 10.1016/j.crwh.2024.e00670. eCollection 2024 Dec.
Liposarcoma of the uterine corpus represents an exceptionally rare tumor, with few cases documented in the literature, underscoring its unique histopathologic characteristics and management challenges. This case describes the clinical management of a 57-year-old patient with well-differentiated liposarcoma of the uterine corpus who presented with a three-month history of abdominal pain and distension. She underwent an abdominal hysterectomy followed by chemotherapy but experienced local recurrence in the mesentery and retroperitoneum after 21 months. Tumor resection was performed again, followed by chemotherapy, but the patient experienced a second recurrence 15 months later, involving the small intestine, vaginal stump, and ureter, with evidence of dedifferentiated liposarcoma. A third surgical resection was carried out without administering chemotherapy and the patient remained asymptomatic at follow-up appointments every 3 months for a year. This case highlights the importance of acknowledging the aggressive nature of recurrent liposarcoma, especially its transition into dedifferentiated liposarcoma, and the need for tailored management strategies.
子宫体脂肪肉瘤是一种极为罕见的肿瘤，文献记载的病例很少，这凸显了其独特的组织病理学特征和管理挑战。本病例描述了一名57岁子宫体高分化脂肪肉瘤患者的临床治疗情况，该患者有三个月的腹痛和腹胀病史。她接受了腹式子宫切除术，随后进行化疗，但21个月后在肠系膜和腹膜后出现局部复发。再次进行肿瘤切除，随后进行化疗，但15个月后患者再次复发，累及小肠、阴道残端和输尿管，有去分化脂肪肉瘤的证据。进行了第三次手术切除，未进行化疗，患者在一年中每3个月的随访预约中均无症状。本病例强调了认识复发性脂肪肉瘤侵袭性本质的重要性，尤其是其向去分化脂肪肉瘤的转变，以及制定个性化管理策略的必要性。
