Kishimoto Yo, Kishimoto Ayami Ohno, Yamada Yosuke, Kitano Masayuki, Kitada Yuji, Kitamura Morimasa, Tateya Ichiro, Sonobe Makoto, Omori Koichi
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
Department of Diagnosic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
Mol Clin Oncol. 2019 Sep;11(3):219-224. doi: 10.3892/mco.2019.1882. Epub 2019 Jun 18.
Liposarcoma is one of the most common soft tissue tumors that affect adults. Liposarcoma is typically identified in the retroperitoneum, trunk and extremities as a slow-growing mass, yet is rare in the thyroid gland. Herein, we report a case of dedifferentiated liposarcoma that developed in the thyroid gland, and performed a literature review. A 66-year-old male with a history of well-differentiated liposarcoma in the thymus presented with a rapidly enlarging mass in the thyroid gland. Malignancy was suspected due to the local extension of the tumor, and complete resection of the tumor was achieved. Tissue diagnosis from the tumor following surgery revealed that dedifferentiated liposarcoma, and tumor progression was difficult to control with adjuvant radiation and chemotherapy. This is, to the best of our knowledge, the first case to report dedifferentiated liposarcoma in the thyroid gland, and the difficulty in initial diagnosis as well as the aggressive features of dedifferentiated liposarcoma are highlighted.
脂肪肉瘤是影响成年人的最常见软组织肿瘤之一。脂肪肉瘤通常在腹膜后、躯干和四肢被发现为生长缓慢的肿块，但在甲状腺中罕见。在此，我们报告一例发生于甲状腺的去分化脂肪肉瘤病例，并进行文献复习。一名66岁男性，有胸腺高分化脂肪肉瘤病史，现甲状腺出现迅速增大的肿块。由于肿瘤局部扩展，怀疑为恶性，遂行肿瘤完整切除。术后肿瘤组织诊断为去分化脂肪肉瘤，辅助放疗和化疗难以控制肿瘤进展。据我们所知，这是首例报道的甲状腺去分化脂肪肉瘤病例，强调了其初始诊断的困难以及去分化脂肪肉瘤的侵袭性特征。
